Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06NEB
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| Former ID |
DNC006565
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| Drug Name |
Ac-hPhe-Leu-Phe-LeuVSMe
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C35H50N4O6S
|
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| Canonical SMILES |
CC(C)CC(C=CS(=O)(=O)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(C<br />)C)NC(=O)C(CCC2=CC=CC=C2)NC(=O)C
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| InChI |
1S/C35H50N4O6S/c1-24(2)21-29(19-20-46(6,44)45)37-34(42)32(23-28-15-11-8-12-16-28)39-35(43)31(22-25(3)4)38-33(41)30(36-26(5)40)18-17-27-13-9-7-10-14-27/h7-16,19-20,24-25,29-32H,17-18,21-23H2,1-6H3,(H,36,40)(H,37,42)(H,38,41)(H,39,43)/b20-19+/t29-,30+,31+,32+/m1/s1
|
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| InChIKey |
UIUWSHIRBDIYGM-QLEUBDALSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Cathepsin B | Target Info | Inhibitor | [1] | |
| Cathepsin S | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Lysosome | ||||
| Antigen processing and presentationhsa04142:Lysosome | |||||
| Phagosome | |||||
| Antigen processing and presentation | |||||
| Tuberculosis | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| IL2 Signaling PathwayNetPath_22:Leptin Signaling Pathway | |||||
| IL2 Signaling Pathway | |||||
| Reactome | Collagen degradation | ||||
| Trafficking and processing of endosomal TLR | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway | |||||
| Degradation of the extracellular matrix | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | Class I MHC mediated antigen processing & presentation | ||||
| Trafficking and processing of endosomal TLR | |||||
| References | |||||
| REF 1 | J Med Chem. 2006 May 18;49(10):2953-68.Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors. | ||||
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