| Drug General Information |
| Drug ID |
D05TGU
|
| Former ID |
DNC010831
|
| Drug Name |
1,1,1,3-Tetrafluoro-6-phenylhexan-2-one
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H12F4O
|
| Canonical SMILES |
C1=CC=C(C=C1)CCCC(C(=O)C(F)(F)F)F
|
| InChI |
1S/C12H12F4O/c13-10(11(17)12(14,15)16)8-4-7-9-5-2-1-3-6-9/h1-3,5-6,10H,4,7-8H2
|
| InChIKey |
ZJWMBXPFXFSELY-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytosolic phospholipase A2 |
Target Info |
Inhibitor |
[1]
|
|---|
|
BioCyc Pathway
|
Phospholipases
|
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KEGG Pathway
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Glycerophospholipid metabolism
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Ether lipid metabolism
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Arachidonic acid metabolism
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Linoleic acid metabolism
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alpha-Linolenic acid metabolism
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Metabolic pathways
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MAPK signaling pathway
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Ras signaling pathway
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Vascular smooth muscle contraction
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VEGF signaling pathway
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Platelet activation
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Fc epsilon RI signaling pathway
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Fc gamma R-mediated phagocytosis
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Glutamatergic synapse
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Serotonergic synapse
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Long-term depression
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Inflammatory mediator regulation of TRP channels
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GnRH signaling pathway
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Ovarian steroidogenesis
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Oxytocin signaling pathway
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Choline metabolism in cancer
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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Endothelin signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Oxidative stress response
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VEGF signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Fc-epsilon receptor I signaling in mast cells
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Endothelins
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PDGFR-beta signaling pathway
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Signaling mediated by p38-alpha and p38-beta
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast Cells
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Reactome
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Acyl chain remodelling of PC
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Acyl chain remodelling of PE
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Acyl chain remodelling of PI
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ADP signalling through P2Y purinoceptor 1
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Platelet sensitization by LDL
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WikiPathways
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Prostaglandin Synthesis and Regulation
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p38 MAPK Signaling Pathway
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Glycerophospholipid biosynthesis
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Arachidonic acid metabolism
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PDGF Pathway
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Integrated Pancreatic Cancer Pathway
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AGE/RAGE pathway
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Opioid Signalling
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Signal amplification
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Platelet homeostasis
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| References |
| REF 1 | J Med Chem. 2010 May 13;53(9):3602-10.Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. |
|---|
