Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0EM1C
|
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| Former ID |
DIB019124
|
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| Drug Name |
Chk2 inhibitor II
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H14ClN3O2
|
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| InChI |
InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
|
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| InChIKey |
UXGJAOIJSROTTN-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
14946094, 24724438, 26758462, 29217525, 46065591, 53800940, 75566488, 85301072, 91146360, 99302680, 103439921, 104219750, 139865336, 139865341, 144221240, 162248071, 163123195, 163688374, 170484625, 175607470, 178102577, 179694520, 204378863, 208265147, 210275017, 210280655, 223704974, 227904993, 243086193, 246265614, 252215134, 252477940
|
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| Target and Pathway | |||||
| Target(s) | Serine/threonine-protein kinase Chk2 | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Cell cycle | ||||
| p53 signaling pathway | |||||
| HTLV-I infection | |||||
| Pathway Interaction Database | ATM pathway | ||||
| FOXM1 transcription factor network | |||||
| p53 pathway | |||||
| PLK3 signaling events | |||||
| Reactome | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | ||||
| G2/M DNA damage checkpoint | |||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
| WikiPathways | DNA Damage Response | ||||
| ATM Signaling Pathway | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Integrated Cancer pathway | |||||
| Cell Cycle | |||||
| miRNA Regulation of DNA Damage Response | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5954). | ||||
| REF 2 | Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | ||||
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