Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09WYX
|
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| Former ID |
DNAP001529
|
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| Drug Name |
Deflazacort
|
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| Synonyms |
Deflan (TN)
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| Drug Type |
Small molecular drug
|
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| Indication | Duchenne muscular dystrophy [ICD10:G71.0] | Approved | [1], [2], [3] | ||
| Company |
Ptc Therap
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C25H31NO6
|
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| Canonical SMILES |
CC1=NC2(C(O1)CC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)C<br />OC(=O)C
|
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| InChI |
1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3
|
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| InChIKey |
FBHSPRKOSMHSIF-UHFFFAOYSA-N
|
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| CAS Number |
CAS 14484-47-0
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| SuperDrug ATC ID |
H02AB13
|
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| Target and Pathway | |||||
| Target(s) | Glucocorticoid receptor | Target Info | Modulator | [4] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| TCR Signaling Pathway | |||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Signaling events mediated by HDAC Class II | |||||
| FOXA2 and FOXA3 transcription factor networks | |||||
| Glucocorticoid receptor regulatory network | |||||
| Regulation of Androgen receptor activity | |||||
| AP-1 transcription factor network | |||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| SIDS Susceptibility Pathways | |||||
| Nuclear Receptors Meta-Pathway | |||||
| Endoderm Differentiation | |||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||||
| Adipogenesis | |||||
| Circadian Clock | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01817322) Kidney Graft Function Under the Immunosuppression Strategies. U.S. National Institutes of Health. | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 3 | Drugs@FDA (Edaravone) | ||||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | ||||
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