| Drug General Information |
| Drug ID |
D09LPL
|
| Former ID |
DNC004132
|
| Drug Name |
SU-11652
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C22H27ClN4O2
|
| InChI |
InChI=1S/C22H27ClN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
|
| InChIKey |
XPLJEFSRINKZLC-ATVHPVEESA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
8034463, 10318719, 10318955, 11061330, 14981640, 26759573, 39301728, 47499818, 57361295, 74593832, 99302781, 99444480, 103175627, 113911641, 134341337, 137184666, 140170705, 160969064, 163687282, 175607440, 177748402, 178102665, 179230473, 204359716, 228252546
|
| Target and Pathway |
| Target(s) |
Beta platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Alpha platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[2]
|
| Vascular endothelial growth factor receptor 1 |
Target Info |
Inhibitor |
[2]
|
| Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[2]
|
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KEGG Pathway
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MAPK signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
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PI3K-Akt signaling pathway
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Focal adhesion
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Gap junction
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Regulation of actin cytoskeleton
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HTLV-I infection
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Pathways in cancer
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MicroRNAs in cancer
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Glioma
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Prostate cancer
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Melanoma
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Central carbon metabolism in cancer
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Choline metabolism in cancerhsa04010:MAPK signaling pathway
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Endocytosis
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Choline metabolism in cancerhsa04014:Ras signaling pathway
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HIF-1 signaling pathway
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Transcriptional misregulation in cancer
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Rheumatoid arthritishsa04014:Ras signaling pathway
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VEGF signaling pathway
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Proteoglycans in cancer
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NetPath Pathway
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TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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PDGF signaling pathwayP00005:Angiogenesis
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VEGF signaling pathway
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Pathway Interaction Database
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Signaling events mediated by PTP1B
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Beta3 integrin cell surface interactions
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S1P3 pathway
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Nectin adhesion pathway
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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PDGFR-beta signaling pathway
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Validated targets of C-MYC transcriptional repression
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PDGF receptor signaling networkatf2_pathway:ATF-2 transcription factor network
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PDGFR-alpha signaling pathway
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PDGF receptor signaling networkglypican_1pathway:Glypican 1 network
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HIF-2-alpha transcription factor network
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VEGF and VEGFR signaling network
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
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Integrins in angiogenesis
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Signaling events mediated by VEGFR1 and VEGFR2
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Notch-mediated HES/HEY network
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Reactome
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PIP3 activates AKT signaling
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Constitutive Signaling by Aberrant PI3K in Cancer
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RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
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RAF/MAP kinase cascadeR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
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VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
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VEGF binds to VEGFR leading to receptor dimerization
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Integrin cell surface interactions
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EPHA-mediated growth cone collapse
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VEGFA-VEGFR2 Pathway
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VEGFR2 mediated cell proliferation
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WikiPathways
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Regulation of Actin Cytoskeleton
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MAPK Signaling Pathway
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Osteoblast Signaling
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Focal Adhesion
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PIP3 activates AKT signaling
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PDGF Pathway
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Signaling Pathways in Glioblastoma
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Signaling by PDGFWP51:Regulation of Actin Cytoskeleton
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Hair Follicle Development: Organogenesis (Part 2 of 3)
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Cardiac Progenitor Differentiation
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Integrated Pancreatic Cancer Pathway
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Allograft Rejection
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Signaling by PDGF
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AngiogenesisWP306:Focal Adhesion
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Signaling by VEGF
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Nifedipine Activity
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Angiogenesis
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| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6043). |
|---|
| REF 2 | J Med Chem. 2003 Mar 27;46(7):1116-9.Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. |
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