Drug Information

Drug General Information
Drug ID
D0P5SA
Former ID
DAP000375
Drug Name
Fluphenazine
Synonyms
Dapotum; Elinol; Flufenazin; Flufenazina; Fluorfenazine; Fluorophenazine; Fluorphenazine; Fluphenazinum; Ftorphenazine; Pacinol; Phthorphenazine; Prolixine; Sevinol; Siqualine; Siqualon; Triflumethazine; Vespazine; Yespazine; Flufenazina [DCIT]; Fluphenazine hydrochloride; Moditen Hcl; Permitil Concentrate; Prolixin Concentrate; S94; SQ 4918; Anatensol (TN); Apo-Fluphenazine; Dapotum (TN); Dapotum D (TN); Dapotum Injektion (TN); Decanoate (TN); Deconoate (TN); Enanthate (TN); Fludecate (TN); Flunanthate (TN); Fluphenazine (INN); Fluphenazine [INN:BAN]; Fluphenazinum [INN-Latin]; Hydrochloride, Fluphenazine; Lyogen (TN); Modecate (TN); Moditen (TN); Moditen (Tabl or elixir); Moditen Enanthate Injection (TN); Omca (TN); Permitil (TN); Prolixin (TN); Sediten (TN); Selecten (TN); Sevinol (TN); Sinqualone (TN); Trancin (TN); 1-(2-Hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine; 1-(2-Hydroxyethyl)-4-[3-(trifluoromethyl-10-phenothiazinyl)propyl]piperazine; 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-(9CI); 10-(3'-(4"-(beta-Hydroxyethyl)-1"-piperazinyl)-propyl)-3-trifluoromethylphenothiazine; 10-(3'-(4''-(beta-Hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine; 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine; 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol; 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethanol; 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-pipe razinyl)propyl)phenothiazine; 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine; 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol; 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol dihydrochloride; 4-(3-(-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol; 4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol; 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-Piperazineethanol; 4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol; 4-[3-(2-Trifluoromethyl-10-phenothiazyl)-propyl]-1-piperazineethanol
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Approved [1], [2]
Therapeutic Class
Antipsychotic Agents
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C22H26F3N3OS
InChI
InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
InChIKey
PLDUPXSUYLZYBN-UHFFFAOYSA-N
CAS Number
CAS 69-23-8
PubChem Compound ID
3372
PubChem Substance ID
9223, 606306, 841998, 5329924, 7979286, 8152146, 10532904, 11111179, 11111180, 11212325, 11335686, 11360925, 11363183, 11364798, 11365745, 11367360, 11368307, 11369922, 11372419, 11372962, 11374514, 11375522, 11376469, 11378089, 11461897, 11466348, 11467468, 11485013, 11486275, 11489015, 11491235, 11492643, 11494103, 14832617, 24263032, 26751625, 29222507, 46506645, 47291093, 47291094, 47365145, 47588956, 47588957, 47662238, 47662239, 47736435, 47885368, 48110419, 48259193, 48259194
SuperDrug ATC ID
N05AB02
SuperDrug CAS ID
cas=000069238
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Modulator [3]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
REF 1The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain. Psychopharmacology (Berl). 2008 Jan;195(4):559-68. Epub 2007 Sep 23.
REF 2(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 204).
REF 3Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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