| Drug General Information |
| Drug ID |
D00VXM
|
| Former ID |
DIB019782
|
| Drug Name |
droxinostat
|
| Synonyms |
NS-41080; NS41080
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C11H14ClNO3
|
| InChI |
InChI=1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)
|
| InChIKey |
JHSXDAWGLCZYSM-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
3395519, 4294610, 7976312, 8089390, 8683016, 11177099, 12240829, 16777079, 17457418, 40378155, 47868302, 48769034, 49763171, 74777775, 87926768, 99437145, 105767842, 113490614, 117934896, 121361124, 124757236, 124781334, 124889779, 125164040, 130982904, 131480871, 134964552, 136340192, 136367418, 136367960, 136946693, 137052797, 139550249, 144047742, 144115925, 152258505, 160644544, 160647340, 162011831, 162037593, 162202706, 164193979, 164914325, 169565171, 174531821, 175608163, 175614199, 179179626, 185965244, 228463896
|
| Target and Pathway |
| Target(s) |
Histone deacetylase-3 |
Target Info |
Inhibitor |
[1]
|
|---|
| Histone Deacetylase 8 |
Target Info |
Inhibitor |
[1]
|
| Histone deacetylase 6 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Thyroid hormone signaling pathway
|
|
Alcoholism
|
|
Viral carcinogenesishsa05034:Alcoholism
|
|
Viral carcinogenesis
|
|
PANTHER Pathway
|
Wnt signaling pathwayP00057:Wnt signaling pathway
|
|
Pathway Interaction Database
|
Signaling events mediated by HDAC Class II
|
|
Signaling events mediated by HDAC Class I
|
|
Retinoic acid receptors-mediated signaling
|
|
Validated targets of C-MYC transcriptional repression
|
|
Regulation of retinoblastoma proteinhdac_classi_pathway:Signaling events mediated by HDAC Class Ihdac_classii_pathway:Signaling events mediated by HDAC Class II
|
|
Reactome
|
NOTCH1 Intracellular Domain Regulates Transcription
|
|
Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
|
|
HDACs deacetylate histonesR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
|
|
Assembly of the primary cilium
|
|
WikiPathways
|
Integrated Pancreatic Cancer Pathway
|
|
Neural Crest Differentiation
|
|
Cell CycleWP2858:Ectoderm Differentiation
|
|
Cell Cycle
|
| References |
| REF 1 | Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56. |
|---|
