| Drug General Information |
| Drug ID |
D09VRX
|
| Former ID |
DNC005881
|
| Drug Name |
2-(4-methyl-1H-benzo[d]imidazol-2-yl)quinoxaline
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H12N4
|
| Canonical SMILES |
CC1=C2C(=CC=C1)NC(=N2)C3=NC4=CC=CC=C4N=C3
|
| InChI |
1S/C16H12N4/c1-10-5-4-8-13-15(10)20-16(19-13)14-9-17-11-6-2-3-7-12(11)18-14/h2-9H,1H3,(H,19,20)
|
| InChIKey |
HQNVISKJTIKRQJ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A3 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Vascular smooth muscle contraction
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Parkinson's disease
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Alcoholismhsa04022:cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Morphine addiction
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NetPath Pathway
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TCR Signaling Pathway
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RANKL Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Pathway Interaction Database
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HIF-2-alpha transcription factor network
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Reactome
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Adenosine P1 receptors
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G alpha (i) signalling eventsR-HSA-187024:NGF-independant TRKA activation
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G alpha (s) signalling events
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
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G alpha (i) signalling events
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WikiPathways
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Nucleotide GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCRs, OtherWP80:Nucleotide GPCRs
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Monoamine Transport
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NGF signalling via TRKA from the plasma membrane
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GPCR ligand binding
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GPCR downstream signaling
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| References |
| REF 1 | J Med Chem. 2008 Mar 27;51(6):1764-70. Epub 2008 Feb 13.Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. |
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