Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J3BY
|
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| Former ID |
DIB007694
|
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| Drug Name |
Pimagedine HCl
|
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| Drug Type |
Small molecular drug
|
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| Indication | Diabetic kidney disease [ICD10:E11.22] | Phase 2/3 | [1] | ||
| Company |
Synvista Therapeutics
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
CH7ClN4
|
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| Canonical SMILES |
Cl.NNC(=N)N
|
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| InChI |
1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
|
||||
| InChIKey |
UBDZFAGVPPMTIT-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Nitric oxide synthase, inducible | Target Info | Inhibitor | [2] | |
| BioCyc Pathway | Citrulline-nitric oxide cycle | ||||
| KEGG Pathway | Arginine biosynthesis | ||||
| Arginine and proline metabolism | |||||
| Metabolic pathways | |||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Peroxisome | |||||
| Salmonella infection | |||||
| Pertussis | |||||
| Leishmaniasis | |||||
| Chagas disease (American trypanosomiasis) | |||||
| Toxoplasmosis | |||||
| Amoebiasis | |||||
| Tuberculosis | |||||
| Pathways in cancer | |||||
| Small cell lung cancer | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| IL2 Signaling Pathway | |||||
| Pathway Interaction Database | IL12-mediated signaling events | ||||
| Alpha9 beta1 integrin signaling events | |||||
| ATF-2 transcription factor network | |||||
| IL23-mediated signaling events | |||||
| Signaling mediated by p38-alpha and p38-beta | |||||
| HIF-1-alpha transcription factor network | |||||
| Reactome | ROS production in response to bacteria | ||||
| Nitric oxide stimulates guanylate cyclase | |||||
| WikiPathways | Type II interferon signaling (IFNG) | ||||
| Spinal Cord Injury | |||||
| AGE/RAGE pathway | |||||
| Effects of Nitric Oxide | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006816) | ||||
| REF 2 | Nitric oxide associated with iNOS expression inhibits acetylcholinesterase activity and induces memory impairment during acute hypobaric hypoxia. Brain Res. 2008 Sep 16;1230:138-49. | ||||
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