Drug Information

Drug General Information
Drug ID
D05LDQ
Former ID
DNCL003399
Drug Name
BAY 94-9027
Synonyms
Peg rFVIII
Indication Hemophilia; Stroke [ICD9: 286, 434.91, 437.6, 453, 671.5, 671.9; ICD10:D66-D68, I61-I63, I80-I82] Phase 3 [548006]
Company
Bayer HealthCare Pharmaceuticals
Target and Pathway
Target(s) Coagulation Factor VIIIa Target Info Modulator [532784]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
PathWhiz Pathway Coagulation
Reactome Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
COPII (Coat Protein 2) Mediated Vesicle Transport
Cargo concentration in the ER
WikiPathways Complement and Coagulation Cascades
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 548006Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021112)
Ref 532784Phase I study of BAY 94-9027, a PEGylated B-domain-deleted recombinant factor VIII with an extended half-life, in subjects with hemophilia A. J Thromb Haemost. 2014 Apr;12(4):488-96.

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