Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M8VL
|
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| Former ID |
DIB013300
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| Drug Name |
GW-870086-X
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| Synonyms |
Glucocorticoid agonist (asthma), GlaxoSmithKline; GW-870086-X (inhaled, asthma), GlaxoSmithKline
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| Indication | Asthma [ICD10:J45] | Phase 2 | [1], [2] | ||
| Company |
GlaxoSmithKline plc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
CC1(C)C(C)(C)C1C(=O)O[C@@]1(C(=O)OCC#N)[C@]2(C[C@@H]([C<br />@@]3([C@]4(C=CC(=O)C=C4[C@H](C[C@H]3[C@@H]2C[C@H]1C)F)C<br />)F)O)C
|
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| Target and Pathway | |||||
| Target(s) | Glucocorticoid receptor | Target Info | Agonist | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| TCR Signaling Pathway | |||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Signaling events mediated by HDAC Class II | |||||
| FOXA2 and FOXA3 transcription factor networks | |||||
| Glucocorticoid receptor regulatory network | |||||
| Regulation of Androgen receptor activity | |||||
| AP-1 transcription factor network | |||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| SIDS Susceptibility Pathways | |||||
| Nuclear Receptors Meta-Pathway | |||||
| Endoderm Differentiation | |||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||||
| Adipogenesis | |||||
| Circadian Clock | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00549497) A Randomized Study Evaluating Steroid Hormone Levels, Safety And Tolerability Of GW870086X In Healthy Volunteers. U.S. National Institutes of Health. | ||||
| REF 2 | ClinicalTrials.gov (NCT01299610) A Study to Test the Effect of 2 Different Doses of Topical GW870086X on Atopic Dermatitis Also Including a Postive Control and a Placebo. U.S. National Institutes of Health. | ||||
| REF 3 | Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X. Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2100-7. | ||||
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