Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S6GY
|
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| Former ID |
DIB001862
|
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| Drug Name |
SER-101
|
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| Synonyms |
RO-1160367
|
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| Indication | Congestive heart failure [ICD9: 428; ICD10:I50] | Phase 1 | [1] | ||
| Company |
Roche Holding AG
|
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 4 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT4 type receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033318) | ||||
| REF 2 | Phase I clinical trail of SER101 (RO1160367) for treating heart failure leukemia. Roche. | ||||
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