| Drug General Information |
| Drug ID |
D04NOE
|
| Former ID |
DIB001356
|
| Drug Name |
OTSGC-A24
|
| Synonyms |
Peptide vaccine (gastric cancer), OncoTherapy
|
| Drug Type |
Vaccine
|
| Indication |
Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21]
|
Phase 1/2 |
[1]
|
|---|
| Company |
OncoTherapy Science Inc
|
| Target and Pathway |
| Target(s) |
Vascular endothelial growth factor receptor 1 |
Target Info |
|
[2]
|
|---|
| Vascular endothelial growth factor receptor 2 |
Target Info |
|
[2]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Cytokine-cytokine receptor interaction
|
|
HIF-1 signaling pathway
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
Focal adhesion
|
|
Transcriptional misregulation in cancer
|
|
Rheumatoid arthritishsa04014:Ras signaling pathway
|
|
VEGF signaling pathway
|
|
Proteoglycans in cancer
|
|
NetPath Pathway
|
IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Angiogenesis
|
|
VEGF signaling pathway
|
|
Pathway Interaction Database
|
Glypican 1 network
|
|
HIF-2-alpha transcription factor network
|
|
S1P3 pathway
|
|
VEGF and VEGFR signaling network
|
|
VEGFR1 specific signals
|
|
Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
|
|
Beta3 integrin cell surface interactions
|
|
Signaling events mediated by TCPTP
|
|
SHP2 signaling
|
|
S1P1 pathway
|
|
Integrins in angiogenesis
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Notch-mediated HES/HEY network
|
|
Reactome
|
Neurophilin interactions with VEGF and VEGFR
|
|
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
|
VEGF binds to VEGFR leading to receptor dimerization
|
|
Integrin cell surface interactions
|
|
EPHA-mediated growth cone collapse
|
|
VEGFA-VEGFR2 Pathway
|
|
VEGFR2 mediated cell proliferation
|
|
WikiPathways
|
Focal Adhesion
|
|
Signaling by VEGF
|
|
AngiogenesisWP306:Focal Adhesion
|
|
Nifedipine Activity
|
|
Cardiac Progenitor Differentiation
|
|
Angiogenesis
|
| References |
| REF 1 | ClinicalTrials.gov (NCT01227772) Study of OTSGC-A24 Vaccine in Advanced Gastric Cancer. U.S. National Institutes of Health. |
|---|
| REF 2 | J Clin Oncol 33, 2015 (suppl 3; abstr 65). |
|---|
