Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T09215
|
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| Former ID |
TTDR00619
|
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| Target Name |
Isocitrate lyase
|
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| Gene Name |
icl
|
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| Synonyms |
ICL; Isocitrase; Isocitratase; icl
|
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| Target Type |
Research
|
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| Function |
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway (By similarity).
|
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| BioChemical Class |
Carbon-carbon lyase
|
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| Target Validation |
T09215
|
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| UniProt ID | |||||
| EC Number |
EC 4.1.3.1
|
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| Sequence |
MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQL
HDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQV VRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSH WEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSD VDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEA VKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFD LAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTG STEEGQFH |
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| Inhibitor | 2,2',3-Tribromo-4,4',5,5'-tetrahydroxybibenzyl | Drug Info | [1] | ||
| 3-bromopyruvate | Drug Info | [2] | |||
| 3-nitropropionate | Drug Info | [2] | |||
| 5,5'-methylenebis(3,4-dibromobenzene-1,2-diol) | Drug Info | [1] | |||
| Bis(2,3-dibromo-4,5-dihydroxyphenyl)ether | Drug Info | [1] | |||
| Bis(3-bromo-4,5-dihydroxyphenyl)methanone | Drug Info | [1] | |||
| Glyoxalate, Glyoxylate | Drug Info | [3] | |||
| Halisulfate 1 | Drug Info | [4] | |||
| Hydrohalisulfate 1 | Drug Info | [4] | |||
| Pathways | |||||
| KEGG Pathway | Glyoxylate and dicarboxylate metabolism | ||||
| Metabolic pathways | |||||
| Biosynthesis of secondary metabolites | |||||
| Microbial metabolism in diverse environments | |||||
| Carbon metabolism | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8. Epub 2010 Sep 21.Bromophenols as Candida albicans isocitrate lyase inhibitors. | ||||
| REF 2 | Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol. 2000 Aug;7(8):663-8. | ||||
| REF 3 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 4 | Bioorg Med Chem Lett. 2007 May 1;17(9):2483-6. Epub 2007 Feb 13.Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. | ||||
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