Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T85605
|
||||
| Former ID |
TTDS00097
|
||||
| Target Name |
5-hydroxytryptamine receptor
|
||||
| Synonyms |
5-HT receptor
|
||||
| Target Type |
Successful
|
||||
| Disease | Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42] | ||||
| Cerebrovascular ischaemia [ICD9: 434.91; ICD10: I61-I63] | |||||
| Carcinoid syndrome [ICD10: E34.0] | |||||
| Headache [ICD9: 339, 784.0; ICD10: G43-G44, R51] | |||||
| Hyperprolactinemia; Migraine [ICD9:253.1, 346; ICD10: E22.1, G43] | |||||
| Migraine; Cluster headaches [ICD9: 339.00, 339.01, 339.02, 346; ICD10: G43, G44.0] | |||||
| Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0] | |||||
| Obesity [ICD9: 278; ICD10: E66] | |||||
| Psychotic disorders [ICD9: 290-299; ICD10: F20-F29] | |||||
| Schizophrenia [ICD9: 295; ICD10: F20] | |||||
| Vomiting and nausea [ICD9: 787, 787.0; ICD10: R11] | |||||
| BioChemical Class |
GPCR rhodopsin
|
||||
| Target Validation |
T85605
|
||||
| Drugs and Mode of Action | |||||
| Drug(s) | Metergolin | Drug Info | Approved | Hyperprolactinemia; Migraine | [1] |
| Nafronyl | Drug Info | Approved | Cerebrovascular ischaemia | [1] | |
| Paliperidone | Drug Info | Approved | Schizophrenia | [2], [3], [1] | |
| Pizotyline | Drug Info | Approved | Headache | [4], [1] | |
| Ramosetron | Drug Info | Approved | Vomiting and nausea | [5], [1] | |
| Tandospirone | Drug Info | Approved | Anxiety disorder | [6], [1] | |
| Lu-AA34893 | Drug Info | Phase 2 | Anxiety disorder | [7] | |
| BF-1 | Drug Info | Phase 1 | Migraine; Cluster headaches | [8] | |
| Fenfluramine | Drug Info | Withdrawn from market | Obesity | [9], [10] | |
| Ritanserin | Drug Info | Discontinued in Phase 3 | Anxiety disorder | [11], [12] | |
| HMR-2934 | Drug Info | Terminated | Schizophrenia | [13] | |
| REV-598 | Drug Info | Terminated | Carcinoid syndrome | [14] | |
| RGH-2721 | Drug Info | Terminated | Psychotic disorders | [15] | |
| Modulator | BF-1 | Drug Info | [16] | ||
| Lu-AA34893 | Drug Info | [17] | |||
| Metergolin | Drug Info | [18], [19] | |||
| Nafronyl | Drug Info | [1] | |||
| Pizotyline | Drug Info | [1] | |||
| Ramosetron | Drug Info | [19] | |||
| RGH-2721 | Drug Info | [20] | |||
| Tandospirone | Drug Info | [19] | |||
| Antagonist | EpiCept | Drug Info | [21] | ||
| Fenfluramine | Drug Info | [22] | |||
| HMR-2934 | Drug Info | [13] | |||
| MCI | Drug Info | [23] | |||
| Paliperidone | Drug Info | [1] | |||
| Ritanserin | Drug Info | [24] | |||
| SB 203106 | Drug Info | [25] | |||
| Inhibitor | REV-598 | Drug Info | [26] | ||
| References | |||||
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 2 | ClinicalTrials.gov (NCT02146547) European Long-acting Antipsychotics in Schizophrenia Trial. U.S. National Institutes of Health. | ||||
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7258). | ||||
| REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 93). | ||||
| REF 5 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2301). | ||||
| REF 6 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 55). | ||||
| REF 7 | ClinicalTrials.gov (NCT00622245) Efficacy and Safety of Lu AA34893 in Patients With Bipolar Depression. U.S. National Institutes of Health. | ||||
| REF 8 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8424). | ||||
| REF 9 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4613). | ||||
| REF 10 | Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21. | ||||
| REF 11 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 97). | ||||
| REF 12 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000237) | ||||
| REF 13 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. | ||||
| REF 14 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819) | ||||
| REF 15 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004008) | ||||
| REF 16 | Serotonin (5-HT2B) receptor. SciBX 4(19); doi:10.1038/scibx.2011.534. May 12 2011 | ||||
| REF 17 | Encyclopedia of Psychopharmacology. Ian Stolerman. 2010. Page(105). | ||||
| REF 18 | Endocrine profile and therapeutic employment of a new prolactin-lowering drug, metergoline. Gynecol Obstet Invest. 1980;11(1):1-16. | ||||
| REF 19 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
| REF 20 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004008) | ||||
| REF 21 | Emerging therapies for neuropathic pain. Expert Opin Emerg Drugs. 2005 Feb;10(1):95-108. | ||||
| REF 22 | Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418. | ||||
| REF 23 | Effect of a serotonin receptor antagonist on interleukin-6-induced pulmonary hypertension in rats. Chest. 2001 Feb;119(2):554-61. | ||||
| REF 24 | Combined treatment of portal hypertension with ritanserin and propranolol in conscious and unrestrained cirrhotic rats. Hepatology. 1992 May;15(5):878-82. | ||||
| REF 25 | 5-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58. | ||||
| REF 26 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819) | ||||
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