Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T85944
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| Former ID |
TTDR00865
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| Target Name |
UDP-3-O-[3-hydroxymyristoyl] n-acetylglucosamine deacetylase
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| Gene Name |
lpxC
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| Synonyms |
EnvA protein; LpxC; UDP-3-O-acyl-GlcNAc deacetylase; lpxC
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| Target Type |
Research
|
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| Function |
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
|
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| BioChemical Class |
Carbon-nitrogen hydrolase
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| UniProt ID | |||||
| EC Number |
EC 3.5.1.-
|
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| Sequence |
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGET
TMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQ EQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTS FVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKIL DAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPA AAV |
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| Inhibitor | 3-(heptyloxy)benzoic acid | Drug Info | [1] | ||
| BB-78484 | Drug Info | [2] | |||
| BB-78485 | Drug Info | [2] | |||
| Cacodylate Ion | Drug Info | [3] | |||
| MYRISTIC ACID | Drug Info | [1] | |||
| Palmitoleic Acid | Drug Info | [3] | |||
| Tu-514 | Drug Info | [3] | |||
| Pathways | |||||
| KEGG Pathway | Lipopolysaccharide biosynthesis | ||||
| Metabolic pathways | |||||
| References | |||||
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
| REF 2 | Antibacterial activities and characterization of novel inhibitors of LpxC. Antimicrob Agents Chemother. 2002 Jun;46(6):1793-9. | ||||
| REF 3 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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