| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T78656 | ||||
| Target Name | 5-hydroxytryptamine 1F receptor | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | WAY-466 | Drug Info | Ki = 17.8 nM | [527381] | |
| LY-334370 | Drug Info | Ki = 1.6 nM | [529496] | ||
| References | |||||
| Ref 527381 | J Med Chem. 2005 Jan 27;48(2):353-6.Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. | ||||
| Ref 529496 | J Med Chem. 2008 Jun 26;51(12):3609-16. Epub 2008 May 29.Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide. | ||||
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