| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T37510 | ||||
| Target Name | Coagulation Factor Va | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Drotrecogin alfa | Drug Info | IC50 = 12.8 nM | [552893] | |
| RAZAXABAN | Drug Info | Ki = 19700 nM | [527987] | ||
| References | |||||
| Ref 552893 | Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity. Stroke. 2009 May;40(5):1864-9. doi: 10.1161/STROKEAHA.108.536680. Epub 2008 Dec 4. | ||||
| Ref 527987 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1795-8. Epub 2006 Jan 24.Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors. | ||||
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