| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T83001 | ||||
| Target Name | Dopamine reuptake | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | DOV 21947 | Drug Info | Ki = 96 nM | [552331] | |
| Cocaine | Drug Info | Ki = 304 nM | [552643] | ||
| Phenmetrazine | Drug Info | EC50 = 131 nM | [535503] | ||
| DOV-216303 | Drug Info | Ki = 78 nM | [527289] | ||
| References | |||||
| Ref 552331 | Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104. | ||||
| Ref 552643 | Therapeutic potential of monoamine transporter substrates. Curr Top Med Chem. 2006;6(17):1845-59. | ||||
| Ref 535503 | Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain. Eur J Pharmacol. 2002 Jun 28;447(1):51-7. | ||||
| Ref 527289 | J Clin Pharmacol. 2004 Dec;44(12):1360-7.DOV 216,303, a "triple" reuptake inhibitor: safety, tolerability, and pharmacokinetic profile. | ||||
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