Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T35940 | ||||
Target Name | Dual specificity mitogen-activated protein kinase kinase 1 | ||||
Target Type | Discontinued |
||||
Drug Potency against Target | 4,5-Dibromo-1H-pyrrole-2-carboxylic acid amide | Drug Info | IC50 = 2500 nM | [526243] | |
REVERSINE | Drug Info | IC50 = 8 nM | [528890] | ||
5-phenylamino-4-cyano-3-hydroxy-isothiazole | Drug Info | IC50 = 7000 nM | [528219] | ||
ALDISIN | Drug Info | IC50 = 2500 nM | [526243] | ||
OROIDIN | Drug Info | IC50 = 2500 nM | [526243] | ||
DEBROMOHYMENIALDISINE | Drug Info | IC50 = 2500 nM | [526243] | ||
References | |||||
Ref 526243 | J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). | ||||
Ref 528890 | Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10482-7. Epub 2007 Jun 12.Reversine increases the plasticity of lineage-committed mammalian cells. | ||||
Ref 528219 | Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. Epub 2006 May 24.Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors. | ||||
Ref 526243 | J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). | ||||
Ref 526243 | J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). | ||||
Ref 526243 | J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). |
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