Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T11754 | ||||
Target Name | Fatty-acid amide hydrolase | ||||
Target Type | Successful |
||||
Drug Potency against Target | 1-Biphenyl-4-ylmethylmaleimide | Drug Info | IC50 = 16600 nM | [530251] | |
Phenyl-1,4-bismaleimide | Drug Info | IC50 = 13490 nM | [530251] | ||
N-arachidonylmaleimide | Drug Info | IC50 = 2180 nM | [530251] | ||
7-Phenyl-1-(2H-tetrazol-5-yl)-heptan-1-one | Drug Info | IC50 = 600 nM | [529594] | ||
1-(oxazol-2-yl)octadec-9-en-1-one | Drug Info | Ki = 100 nM | [529594] | ||
1-(5-phenyloxazol-2-yl)octadec-9-en-1-one | Drug Info | Ki = 320 nM | [529594] | ||
(Z)-1-(pyridazin-3-yl)octadec-9-en-1-one | Drug Info | Ki = 130 nM | [529193] | ||
N-(2-hydroxyethyl)linoleoylamide | Drug Info | IC50 = 7580 nM | [529848] | ||
1-(oxazol-2-yl)-4-(piperidin-4-yl)butan-1-one | Drug Info | IC50 = 5700 nM | [529327] | ||
1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one | Drug Info | IC50 = 760 nM | [530576] | ||
3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate | Drug Info | IC50 = 3000 nM | [530218] | ||
3-(4,5-Dihydrooxazol-2-yl)phenyl propylcarbamate | Drug Info | IC50 = 33 nM | [530218] | ||
VER-156084 | Drug Info | IC50 = 531 nM | [530200] | ||
JNJ-1661010 | Drug Info | IC50 = 34 nM | [529638] | ||
Benzo[b]thiophen-2-ylboronic acid | Drug Info | IC50 = 150 nM | [529790] | ||
4-(4,5-dihydrothiazol-2-yl)phenyl butylcarbamate | Drug Info | IC50 = 520 nM | [529975] | ||
4-(1,2,3-thiadiazol-4-yl)phenyl hexylcarbamate | Drug Info | IC50 = 19 nM | [529975] | ||
Cyclohexyl biphenyl-4-ylcarbamate | Drug Info | IC50 = 17000 nM | [529975] | ||
2-fluorophenyl 4-(dodecyloxy)phenylcarbamate | Drug Info | IC50 = 13 nM | [530604] | ||
(Z)-1-(4-phenyloxazol-2-yl)octadec-9-en-1-one | Drug Info | Ki = 490 nM | [529193] | ||
1-(5-(pyridin-2-yl)oxazol-2-yl)dodecan-1-one | Drug Info | Ki = 2.2 nM | [529193] | ||
4-(thiazol-2-yl)phenyl butylcarbamate | Drug Info | IC50 = 520 nM | [528323] | ||
HTS-00798 | Drug Info | IC50 = 7000 nM | [528323] | ||
N-(2-iodoethyl)linoleoylamide | Drug Info | IC50 = 7330 nM | [529848] | ||
Chlorphrifos oxon | Drug Info | IC50 = 460 nM | [529440] | ||
2-(7-phenylheptanoyl)oxazole-5-carboxylic acid | Drug Info | IC50 = 900 nM | [529603] | ||
(+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate | Drug Info | IC50 = 8200 nM | [529008] | ||
(+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate | Drug Info | IC50 = 11000 nM | [529008] | ||
OL-135 | Drug Info | Ki = 4.7 nM | [530527] | ||
Methyl icosylphosphonofluoridate | Drug Info | IC50 = 0.1 nM | [529659] | ||
Isopropyl 4-nitrophenyl dodecylphosphonate | Drug Info | IC50 = 3 nM | [529659] | ||
Octane-1-sulfonyl fluoride | Drug Info | IC50 = 1.9 nM | [529659] | ||
1,1,1-Trifluoro-tridecan-2-one | Drug Info | IC50 = 10000 nM | [527476] | ||
1-(5-Pyridin-2-yl-oxazol-2-yl)-octadec-9-yn-1-one | Drug Info | IC50 = 20 nM | [527476] | ||
4-(cyclohexylmethylcarbamoyloxy)benzoic acid | Drug Info | IC50 < 100 nM | [529791] | ||
VER-156084 | Drug Info | IC50 = 188 nM | [530200] | ||
Thiopental | Drug Info | IC50 = 2000000 nM | [529791] | ||
Ethyl octylfluorophosphonate | Drug Info | IC50 = 0.4 nM | [529440] | ||
Benzofuran-2-ylboronic acid | Drug Info | IC50 = 330 nM | [529790] | ||
BTNP | Drug Info | IC50 = 800 nM | [529791] | ||
1-Biphenyl-4-ylmaleimide | Drug Info | IC50 = 5890 nM | [530251] | ||
1,10-(methylenedi-4,1-phenylene)bismaleimide | Drug Info | IC50 = 10700 nM | [530251] | ||
Biphenyl-3-ylcarbamic acid cyclohexyl ester | Drug Info | IC50 = 5650 nM | [530251] | ||
3'-carbamoylbiphenyl-3-yl 6-phenylhexylcarbamate | Drug Info | IC50 = 14 nM | [529791] | ||
3-methoxyphenylboronic acid | Drug Info | IC50 = 1900 nM | [529790] | ||
LY-2183240 | Drug Info | IC50 = 12.4 nM | [529791] | ||
2-(biphenyl-4-yl)vinylboronic acid | Drug Info | IC50 = 14 nM | [529790] | ||
Biphenyl-4-ylboronic acid | Drug Info | IC50 = 21 nM | [529790] | ||
3-(ethoxycarbonyl)phenylboronic acid | Drug Info | IC50 = 120 nM | [529790] | ||
3-(trifluoromethyl)phenylboronic acid | Drug Info | IC50 = 80 nM | [529790] | ||
Phenyl Boronic acid | Drug Info | IC50 = 2600 nM | [529790] | ||
4-nitrophenylboronic acid | Drug Info | IC50 = 210 nM | [529790] | ||
Phenethylboronic acid | Drug Info | IC50 = 1300 nM | [529790] | ||
4-nonylphenylboronic acid | Drug Info | IC50 = 9.1 nM | [529790] | ||
3-cyanophenylboronic acid | Drug Info | IC50 = 1600 nM | [529790] | ||
3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 1350 nM | [529157] | ||
1-Benzooxazol-2-yl-6-phenyl-hexan-1-one | Drug Info | IC50 = 10000 nM | [527476] | ||
(Z)-1,1,1-Trifluoro-nonadec-10-en-2-one | Drug Info | IC50 = 4500 nM | [527476] | ||
1,4-bis(malimido)xylene | Drug Info | IC50 = 16600 nM | [530251] | ||
2-methoxyphenylboronic acid | Drug Info | IC50 = 13000 nM | [529790] | ||
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate | Drug Info | IC50 = 240 nM | [530576] | ||
4-(1,2,3-thiadiazol-4-yl)phenyl butylcarbamate | Drug Info | IC50 = 160 nM | [529975] | ||
1-(1,3,4-Oxadiazol-2-yl)-7-phenylheptan-1-one | Drug Info | IC50 = 1 nM | [529594] | ||
4-fluorophenylboronic acid | Drug Info | IC50 = 1500 nM | [529790] | ||
4-(trifluoromethyl)phenylboronic acid | Drug Info | IC50 = 36 nM | [529790] | ||
Propan-2-one O-4-(heptyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 8.4 nM | [530604] | ||
Propan-2-one O-4-butoxybenzylcarbamoyl oxime | Drug Info | IC50 = 570 nM | [530604] | ||
Benzaldehyde O-4-propoxyphenylcarbamoyl oxime | Drug Info | IC50 = 9.3 nM | [530604] | ||
Benzaldehyde O-4-(hexyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 8 nM | [530604] | ||
2,4-difluorophenyl 4-butoxybenzylcarbamate | Drug Info | IC50 = 8.7 nM | [530604] | ||
Biphenyl-3-ylboronic acid | Drug Info | IC50 = 130 nM | [529790] | ||
1,1,1-Trifluoro-9-phenyl-nonan-2-one | Drug Info | IC50 = 2000 nM | [527476] | ||
1,1,1-Trifluoro-nonadecan-2-one | Drug Info | IC50 = 6400 nM | [527476] | ||
2-(7-phenylheptanoyl)oxazole-4-carboxylic acid | Drug Info | IC50 = 500 nM | [529603] | ||
2-fluorophenyl 4-(octyloxy)phenylcarbamate | Drug Info | IC50 = 19 nM | [530604] | ||
4-methoxyphenylboronic acid | Drug Info | IC50 = 2000 nM | [529790] | ||
6-fluoropyridin-3-ylboronic acid | Drug Info | IC50 = 10000 nM | [529790] | ||
6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 13 nM | [529498] | ||
1-(5-(pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one | Drug Info | Ki = 18 nM | [529594] | ||
2-fluorophenyl 4-(undecyloxy)phenylcarbamate | Drug Info | IC50 = 15 nM | [530604] | ||
2-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate | Drug Info | IC50 = 7.7 nM | [530604] | ||
Propan-2-one O-3-butoxyphenylcarbamoyl oxime | Drug Info | IC50 = 6300 nM | [530604] | ||
Propan-2-one O-4-(octyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 2.4 nM | [530604] | ||
Propan-2-one O-4-(nonyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 2.1 nM | [530604] | ||
Cyclopentylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 34 nM | [529498] | ||
Cyclobutylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 54 nM | [529498] | ||
Propan-2-one O-4-(decyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 2.2 nM | [530604] | ||
1,1,1-Trifluoro-7-phenylheptan-2-one | Drug Info | IC50 = 5000 nM | [527476] | ||
Furan-2-ylmethylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 175 nM | [529498] | ||
Phenethylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 481 nM | [529498] | ||
Allylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 696 nM | [529498] | ||
Benzaldehyde O-4-methoxyphenylcarbamoyl oxime | Drug Info | IC50 = 290 nM | [530604] | ||
Adamant-1-ylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 4089 nM | [529498] | ||
1,1,1-trifluorododecan-2-one | Drug Info | IC50 = 1800 nM | [529157] | ||
2,2-dimethyl-3-methyleneheptadecane | Drug Info | IC50 = 89 nM | [529157] | ||
1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one | Drug Info | IC50 = 4 nM | [529594] | ||
Phenyl 4-(octyloxy)phenylcarbamate | Drug Info | IC50 = 5.4 nM | [530604] | ||
1-(4-chlorooxazol-2-yl)-7-phenylheptan-1-one | Drug Info | Ki = 4 nM | [529603] | ||
8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 5.4 nM | [529498] | ||
Phenyl 1-(4-butoxyphenyl)propylcarbamate | Drug Info | IC50 = 12 nM | [530604] | ||
1-(oxazolo[4,5-b]pyridin-2-yl)octan-1-one | Drug Info | Ki = 0.69 nM | [529193] | ||
4-cyanophenyl ethyl dodecylphosphonate | Drug Info | IC50 = 12 nM | [529659] | ||
Benzaldehyde O-4-(pentyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 3.5 nM | [530604] | ||
N-Hexylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 57 nM | [529498] | ||
7-Phenyl-1-(1,3,4-thiadiazol-2-yl)-heptan-1-one | Drug Info | IC50 = 300 nM | [529594] | ||
7-phenyl-1-(4-phenyloxazol-2-yl)heptan-1-one | Drug Info | Ki = 65 nM | [529603] | ||
1-(1,3,4-oxadiazol-2-yl)octadec-9-en-1-one | Drug Info | Ki = 90 nM | [529594] | ||
4-fluorophenyl 4-butoxybenzylcarbamate | Drug Info | IC50 = 4.6 nM | [530604] | ||
Indan-2-ylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 215 nM | [529498] | ||
2-fluorophenyl 4-butoxybenzylcarbamate | Drug Info | IC50 = 9.2 nM | [530604] | ||
1-(oxazolo[4,5-b]pyridin-2-yl)pentan-1-one | Drug Info | Ki = 50 nM | [529193] | ||
1-(oxazolo[4,5-b]pyridin-2-yl)dodecan-1-one | Drug Info | Ki = 0.57 nM | [529193] | ||
Methyl 2-(7-phenylheptanoyl)oxazole-4-carboxylate | Drug Info | Ki = 3.4 nM | [529603] | ||
Cyclohexylcarbamic acidbiphenyl-3-yl ester | Drug Info | IC50 = 63 nM | [529498] | ||
1-(4-acetyloxazol-2-yl)-7-phenylheptan-1-one | Drug Info | Ki = 2 nM | [529603] | ||
1-(4-methoxyoxazol-2-yl)-7-phenylheptan-1-one | Drug Info | Ki = 740 nM | [529603] | ||
Phenyl 4-(dodecyloxy)phenylcarbamate | Drug Info | IC50 = 1.8 nM | [530604] | ||
(Z)-1-(benzo[d]oxazol-2-yl)octadec-9-en-1-one | Drug Info | Ki = 370 nM | [529193] | ||
1-(4-iodooxazol-2-yl)-7-phenylheptan-1-one | Drug Info | Ki = 6.5 nM | [529603] | ||
Propan-2-one O-4-butoxyphenylcarbamoyl oxime | Drug Info | IC50 = 28 nM | [530604] | ||
1-(oxazol-2-yl)-7-phenylheptan-1-one | Drug Info | IC50 = 2500 nM | [529603] | ||
Biphenyl-3-ylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 3091 nM | [529498] | ||
Benzaldehyde O-4-(decyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 0.35 nM | [530604] | ||
1-(5-methyloxazol-2-yl)-7-phenylheptan-1-one | Drug Info | Ki = 80 nM | [529193] | ||
7-Phenyl-1-(pyridazin-3-yl)-heptan-1-one | Drug Info | IC50 = 3000 nM | [529594] | ||
3-(trifluoromethyl)phenyl 4-butoxybenzylcarbamate | Drug Info | IC50 = 40 nM | [530604] | ||
Naphthalen-2-yl cyclohexylcarbamate | Drug Info | IC50 = 324 nM | [529791] | ||
Phenyl 4-(hexyloxy)phenylcarbamate | Drug Info | IC50 = 31 nM | [530604] | ||
1-(4-bromooxazol-2-yl)-7-phenylheptan-1-one | Drug Info | Ki = 3 nM | [529603] | ||
Benzaldehyde O-4-(nonyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 0.25 nM | [530604] | ||
Benzaldehyde O-4-(octyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 0.43 nM | [530604] | ||
3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 600 nM | [529157] | ||
Benzaldehyde O-4-butoxyphenylcarbamoyl oxime | Drug Info | IC50 = 8.5 nM | [530604] | ||
2-fluorophenyl 4-(hexyloxy)phenylcarbamate | Drug Info | IC50 = 710 nM | [530604] | ||
Phenyl 4-(undecyloxy)phenylcarbamate | Drug Info | IC50 = 1 nM | [530604] | ||
7-Phenyl-1-(thiazol-2-yl)-heptan-1-one | Drug Info | Ki = 800 nM | [529594] | ||
Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate | Drug Info | Ki = 0.9 nM | [529594] | ||
Methylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 13901 nM | [529498] | ||
1-(5-fluorooxazol-2-yl)-7-phenylheptan-1-one | Drug Info | Ki = 30 nM | [529193] | ||
1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one | Drug Info | IC50 = 13900 nM | [529157] | ||
ARACHIDONYL TRIFLUOROMETHYLKETONE | Drug Info | IC50 = 3700 nM | [530576] | ||
Cyclohexylmethylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 66 nM | [529498] | ||
Benzylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 139 nM | [529498] | ||
Phenylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 3942 nM | [529498] | ||
2-(7-phenylheptanoyl)oxazole-4-carbaldehyde | Drug Info | Ki = 55 nM | [529603] | ||
2-(7-phenylheptanoyl)oxazole-5-carbonitrile | Drug Info | IC50 = 7 nM | [529603] | ||
1-(1,3,4-thiadiazol-2-yl)octadec-9-en-1-one | Drug Info | Ki = 170 nM | [529594] | ||
1,1,1-Trifluoro-undecan-2-one | Drug Info | IC50 = 10000 nM | [527476] | ||
2-fluorophenyl 4-butoxyphenylcarbamate | Drug Info | IC50 = 340 nM | [530604] | ||
1-(5-(furan-2-yl)oxazol-2-yl)octadec-9-en-1-one | Drug Info | Ki = 54 nM | [529594] | ||
Benzaldehyde O-4-(heptyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 8.6 nM | [530604] | ||
Propofol | Drug Info | IC50 = 14000 nM | [529791] | ||
4-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate | Drug Info | IC50 = 12 nM | [530604] | ||
3-chlorophenyl 4-butoxybenzylcarbamate | Drug Info | IC50 = 12 nM | [530604] | ||
Propan-2-one O-4-(pentyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 28 nM | [530604] | ||
2-fluorophenyl 4-(decyloxy)phenylcarbamate | Drug Info | IC50 = 9.2 nM | [530604] | ||
Benzaldehyde O-4-ethoxyphenylcarbamoyl oxime | Drug Info | IC50 = 81 nM | [530604] | ||
Nicotinaldehyde O-4-butoxyphenylcarbamoyl oxime | Drug Info | IC50 = 14 nM | [530604] | ||
4-methoxyphenyl 1-(4-butoxyphenyl)propylcarbamate | Drug Info | IC50 = 12 nM | [530604] | ||
2-fluorophenyl 4-phenoxyphenylcarbamate | Drug Info | IC50 = 1300 nM | [530604] | ||
Propan-2-one O-4-propoxyphenylcarbamoyl oxime | Drug Info | IC50 = 210 nM | [530604] | ||
Phenyl 4-(heptyloxy)phenylcarbamate | Drug Info | IC50 = 8.6 nM | [530604] | ||
2-(7-phenylheptanoyl)oxazole-4-carbonitrile | Drug Info | IC50 = 20 nM | [529603] | ||
1-Oxazolo[4,5-b]pyridin-2-yl-octadec-9-yn-1-one | Drug Info | IC50 = 2 nM | [527476] | ||
2-fluorophenyl 4'-ethylbiphenyl-4-ylcarbamate | Drug Info | IC50 = 810 nM | [530604] | ||
4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 9.4 nM | [529498] | ||
2-fluorophenyl 4-(heptyloxy)phenylcarbamate | Drug Info | IC50 = 28 nM | [530604] | ||
Nicotinaldehyde O-4-propoxyphenylcarbamoyl oxime | Drug Info | IC50 = 29 nM | [530604] | ||
2-Cyclohexylacetic acidbiphenyl-3-yl ester | Drug Info | IC50 = 2551 nM | [529498] | ||
7-phenyl-1-(5-phenyloxazol-2-yl)heptan-1-one | Drug Info | IC50 = 80 nM | [529594] | ||
1-(1,2,4-Oxadiazol-3-yl)-7-phenylheptan-1-one | Drug Info | IC50 = 500 nM | [529594] | ||
Phenyl 4-(decyloxy)phenylcarbamate | Drug Info | IC50 = 1.4 nM | [530604] | ||
Propan-2-one O-4-ethoxyphenylcarbamoyl oxime | Drug Info | IC50 = 730 nM | [530604] | ||
Pyridin-3-yl 4-butoxybenzylcarbamate | Drug Info | IC50 = 6.1 nM | [530604] | ||
4-Nitrophenyl 4-Benzylpiperazine-1-carboxylate | Drug Info | IC50 = 930 nM | [530654] | ||
Isopropylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 521 nM | [529498] | ||
3-(decylthio)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 170 nM | [529157] | ||
PHENMEDIPHAM | Drug Info | IC50 = 77 nM | [530469] | ||
2-(7-phenylheptanoyl)oxazole-4-carboxamide | Drug Info | Ki = 1.6 nM | [529603] | ||
PARAOXON | Drug Info | IC50 = 5900 nM | [529440] | ||
Isopropyl dodecylfluorophosphonate | Drug Info | IC50 = 3 nM | [529440] | ||
2-chloro-1-(5-(pyridin-2-yl)oxazol-2-yl)ethanone | Drug Info | Ki = 800 nM | [528884] | ||
Cyclopentyl(5-(pyridin-2-yl)oxazol-2-yl)methanone | Drug Info | Ki = 2500 nM | [528884] | ||
1,1,1-Trifluoro-8-phenyl-octan-2-one | Drug Info | IC50 = 5000 nM | [527476] | ||
1-(5-(pyridin-2-yl)oxazol-2-yl)pentan-1-one | Drug Info | Ki = 3000 nM | [529193] | ||
1-(4-methyloxazol-2-yl)-7-phenylheptan-1-one | Drug Info | Ki = 520 nM | [529603] | ||
BMS-1 | Drug Info | Ki = 2 nM | [529859] | ||
(Z)-2-Methyl-1-oxazol-2-yl-octadec-9-en-1-one | Drug Info | Ki = 1400 nM | [526085] | ||
Propan-2-one O-4-(hexyloxy)phenylcarbamoyl oxime | Drug Info | IC50 = 18 nM | [530604] | ||
(Z)-2,2-Dimethyl-1-oxazol-2-yl-octadec-9-en-1-one | Drug Info | Ki = 14200 nM | [526085] | ||
Dodecane-1-sulfonyl fluoride | Drug Info | IC50 = 2 nM | [529659] | ||
N-(2-iodethyl)arachidonylamide | Drug Info | IC50 = 10070 nM | [529848] | ||
1-(5-(pyridin-2-yl)oxazol-2-yl)octan-1-one | Drug Info | Ki = 49 nM | [529193] | ||
Nicotinaldehyde O-4-ethoxyphenylcarbamoyl oxime | Drug Info | IC50 = 150 nM | [530604] | ||
1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one | Drug Info | IC50 = 14800 nM | [529157] | ||
3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 280 nM | [529157] | ||
1,1,1-trifluoro-3-(hexylthio)propan-2-one | Drug Info | IC50 = 2500 nM | [529157] | ||
3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 3000 nM | [529157] | ||
1,1,1-trifluoro-3-(octylthio)propan-2-one | Drug Info | IC50 = 300 nM | [529157] | ||
1-(oxazol-2-yl)-3-(4-phenoxyphenyl)propan-1-one | Drug Info | IC50 = 500 nM | [529284] | ||
N-Butylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 113 nM | [529498] | ||
4-cyanophenylboronic acid | Drug Info | IC50 = 290 nM | [529790] | ||
N-Octylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | IC50 = 53 nM | [529498] | ||
LY-2318912 | Drug Info | IC50 = 23 nM | [528802] | ||
2-fluorophenylboronic acid | Drug Info | IC50 = 710 nM | [529790] | ||
AR-C70484XX | Drug Info | IC50 = 59 nM | [530576] | ||
3-(biphenyl-4-yl)-1-(oxazol-2-yl)propan-1-one | Drug Info | IC50 = 180 nM | [529284] | ||
References | |||||
Ref 530251 | J Med Chem. 2009 Dec 10;52(23):7410-20.Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. | ||||
Ref 530251 | J Med Chem. 2009 Dec 10;52(23):7410-20.Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. | ||||
Ref 530251 | J Med Chem. 2009 Dec 10;52(23):7410-20.Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. | ||||
Ref 529594 | J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. | ||||
Ref 529594 | J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. | ||||
Ref 529594 | J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. | ||||
Ref 529193 | Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. Epub 2007 Nov 6.Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. | ||||
Ref 529848 | Bioorg Med Chem. 2009 Jan 1;17(1):49-56. Epub 2008 Nov 17.Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. | ||||
Ref 529327 | Bioorg Med Chem Lett. 2008 Mar 15;18(6):2109-13. Epub 2008 Jan 30.Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH). | ||||
Ref 530576 | Bioorg Med Chem. 2010 Jan 15;18(2):945-52. Epub 2009 Nov 17.1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amidehydrolase. | ||||
Ref 530218 | Eur J Med Chem. 2009 Oct;44(10):4179-91. Epub 2009 May 22.Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields. | ||||
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Ref 530200 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. Epub 2009 May 29.Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. | ||||
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Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
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Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
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Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
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Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
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Ref 527476 | J Med Chem. 2005 Mar 24;48(6):1849-56.Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. | ||||
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Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
Ref 529790 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
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Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
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Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 527476 | J Med Chem. 2005 Mar 24;48(6):1849-56.Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. | ||||
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Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
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Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 529193 | Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. Epub 2007 Nov 6.Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. | ||||
Ref 529659 | Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Epub 2008 Aug 6.Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
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Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 529498 | J Med Chem. 2008 Jun 26;51(12):3487-98. Epub 2008 May 29.Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
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Ref 529193 | Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. Epub 2007 Nov 6.Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. | ||||
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Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 529603 | Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. Epub 2008 Jun 28.Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fattyacid amide hydrolase. | ||||
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Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 529193 | Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. Epub 2007 Nov 6.Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. | ||||
Ref 529594 | J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 529791 | J Med Chem. 2008 Dec 11;51(23):7327-43.Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 529603 | Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. Epub 2008 Jun 28.Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fattyacid amide hydrolase. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
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Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 529594 | J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. | ||||
Ref 529594 | J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. | ||||
Ref 529498 | J Med Chem. 2008 Jun 26;51(12):3487-98. Epub 2008 May 29.Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. | ||||
Ref 529193 | Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. Epub 2007 Nov 6.Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
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Ref 529498 | J Med Chem. 2008 Jun 26;51(12):3487-98. Epub 2008 May 29.Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. | ||||
Ref 529498 | J Med Chem. 2008 Jun 26;51(12):3487-98. Epub 2008 May 29.Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. | ||||
Ref 529498 | J Med Chem. 2008 Jun 26;51(12):3487-98. Epub 2008 May 29.Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. | ||||
Ref 529603 | Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. Epub 2008 Jun 28.Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fattyacid amide hydrolase. | ||||
Ref 529603 | Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. Epub 2008 Jun 28.Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fattyacid amide hydrolase. | ||||
Ref 529594 | J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. | ||||
Ref 527476 | J Med Chem. 2005 Mar 24;48(6):1849-56.Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 529594 | J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 529791 | J Med Chem. 2008 Dec 11;51(23):7327-43.Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
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Ref 530604 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors. | ||||
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Ref 529284 | J Med Chem. 2008 Feb 28;51(4):937-47. Epub 2008 Feb 5.Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. |
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