Target Validation Information
Target ID T11754
Target Name Fatty-acid amide hydrolase
Target Type
Successful
Drug Potency against Target 1-Biphenyl-4-ylmethylmaleimide Drug Info IC50 = 16600 nM [530251]
Phenyl-1,4-bismaleimide Drug Info IC50 = 13490 nM [530251]
N-arachidonylmaleimide Drug Info IC50 = 2180 nM [530251]
7-Phenyl-1-(2H-tetrazol-5-yl)-heptan-1-one Drug Info IC50 = 600 nM [529594]
1-(oxazol-2-yl)octadec-9-en-1-one Drug Info Ki = 100 nM [529594]
1-(5-phenyloxazol-2-yl)octadec-9-en-1-one Drug Info Ki = 320 nM [529594]
(Z)-1-(pyridazin-3-yl)octadec-9-en-1-one Drug Info Ki = 130 nM [529193]
N-(2-hydroxyethyl)linoleoylamide Drug Info IC50 = 7580 nM [529848]
1-(oxazol-2-yl)-4-(piperidin-4-yl)butan-1-one Drug Info IC50 = 5700 nM [529327]
1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one Drug Info IC50 = 760 nM [530576]
3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate Drug Info IC50 = 3000 nM [530218]
3-(4,5-Dihydrooxazol-2-yl)phenyl propylcarbamate Drug Info IC50 = 33 nM [530218]
VER-156084 Drug Info IC50 = 531 nM [530200]
JNJ-1661010 Drug Info IC50 = 34 nM [529638]
Benzo[b]thiophen-2-ylboronic acid Drug Info IC50 = 150 nM [529790]
4-(4,5-dihydrothiazol-2-yl)phenyl butylcarbamate Drug Info IC50 = 520 nM [529975]
4-(1,2,3-thiadiazol-4-yl)phenyl hexylcarbamate Drug Info IC50 = 19 nM [529975]
Cyclohexyl biphenyl-4-ylcarbamate Drug Info IC50 = 17000 nM [529975]
2-fluorophenyl 4-(dodecyloxy)phenylcarbamate Drug Info IC50 = 13 nM [530604]
(Z)-1-(4-phenyloxazol-2-yl)octadec-9-en-1-one Drug Info Ki = 490 nM [529193]
1-(5-(pyridin-2-yl)oxazol-2-yl)dodecan-1-one Drug Info Ki = 2.2 nM [529193]
4-(thiazol-2-yl)phenyl butylcarbamate Drug Info IC50 = 520 nM [528323]
HTS-00798 Drug Info IC50 = 7000 nM [528323]
N-(2-iodoethyl)linoleoylamide Drug Info IC50 = 7330 nM [529848]
Chlorphrifos oxon Drug Info IC50 = 460 nM [529440]
2-(7-phenylheptanoyl)oxazole-5-carboxylic acid Drug Info IC50 = 900 nM [529603]
(+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate Drug Info IC50 = 8200 nM [529008]
(+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate Drug Info IC50 = 11000 nM [529008]
OL-135 Drug Info Ki = 4.7 nM [530527]
Methyl icosylphosphonofluoridate Drug Info IC50 = 0.1 nM [529659]
Isopropyl 4-nitrophenyl dodecylphosphonate Drug Info IC50 = 3 nM [529659]
Octane-1-sulfonyl fluoride Drug Info IC50 = 1.9 nM [529659]
1,1,1-Trifluoro-tridecan-2-one Drug Info IC50 = 10000 nM [527476]
1-(5-Pyridin-2-yl-oxazol-2-yl)-octadec-9-yn-1-one Drug Info IC50 = 20 nM [527476]
4-(cyclohexylmethylcarbamoyloxy)benzoic acid Drug Info IC50 < 100 nM [529791]
VER-156084 Drug Info IC50 = 188 nM [530200]
Thiopental Drug Info IC50 = 2000000 nM [529791]
Ethyl octylfluorophosphonate Drug Info IC50 = 0.4 nM [529440]
Benzofuran-2-ylboronic acid Drug Info IC50 = 330 nM [529790]
BTNP Drug Info IC50 = 800 nM [529791]
1-Biphenyl-4-ylmaleimide Drug Info IC50 = 5890 nM [530251]
1,10-(methylenedi-4,1-phenylene)bismaleimide Drug Info IC50 = 10700 nM [530251]
Biphenyl-3-ylcarbamic acid cyclohexyl ester Drug Info IC50 = 5650 nM [530251]
3'-carbamoylbiphenyl-3-yl 6-phenylhexylcarbamate Drug Info IC50 = 14 nM [529791]
3-methoxyphenylboronic acid Drug Info IC50 = 1900 nM [529790]
LY-2183240 Drug Info IC50 = 12.4 nM [529791]
2-(biphenyl-4-yl)vinylboronic acid Drug Info IC50 = 14 nM [529790]
Biphenyl-4-ylboronic acid Drug Info IC50 = 21 nM [529790]
3-(ethoxycarbonyl)phenylboronic acid Drug Info IC50 = 120 nM [529790]
3-(trifluoromethyl)phenylboronic acid Drug Info IC50 = 80 nM [529790]
Phenyl Boronic acid Drug Info IC50 = 2600 nM [529790]
4-nitrophenylboronic acid Drug Info IC50 = 210 nM [529790]
Phenethylboronic acid Drug Info IC50 = 1300 nM [529790]
4-nonylphenylboronic acid Drug Info IC50 = 9.1 nM [529790]
3-cyanophenylboronic acid Drug Info IC50 = 1600 nM [529790]
3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 1350 nM [529157]
1-Benzooxazol-2-yl-6-phenyl-hexan-1-one Drug Info IC50 = 10000 nM [527476]
(Z)-1,1,1-Trifluoro-nonadec-10-en-2-one Drug Info IC50 = 4500 nM [527476]
1,4-bis(malimido)xylene Drug Info IC50 = 16600 nM [530251]
2-methoxyphenylboronic acid Drug Info IC50 = 13000 nM [529790]
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate Drug Info IC50 = 240 nM [530576]
4-(1,2,3-thiadiazol-4-yl)phenyl butylcarbamate Drug Info IC50 = 160 nM [529975]
1-(1,3,4-Oxadiazol-2-yl)-7-phenylheptan-1-one Drug Info IC50 = 1 nM [529594]
4-fluorophenylboronic acid Drug Info IC50 = 1500 nM [529790]
4-(trifluoromethyl)phenylboronic acid Drug Info IC50 = 36 nM [529790]
Propan-2-one O-4-(heptyloxy)phenylcarbamoyl oxime Drug Info IC50 = 8.4 nM [530604]
Propan-2-one O-4-butoxybenzylcarbamoyl oxime Drug Info IC50 = 570 nM [530604]
Benzaldehyde O-4-propoxyphenylcarbamoyl oxime Drug Info IC50 = 9.3 nM [530604]
Benzaldehyde O-4-(hexyloxy)phenylcarbamoyl oxime Drug Info IC50 = 8 nM [530604]
2,4-difluorophenyl 4-butoxybenzylcarbamate Drug Info IC50 = 8.7 nM [530604]
Biphenyl-3-ylboronic acid Drug Info IC50 = 130 nM [529790]
1,1,1-Trifluoro-9-phenyl-nonan-2-one Drug Info IC50 = 2000 nM [527476]
1,1,1-Trifluoro-nonadecan-2-one Drug Info IC50 = 6400 nM [527476]
2-(7-phenylheptanoyl)oxazole-4-carboxylic acid Drug Info IC50 = 500 nM [529603]
2-fluorophenyl 4-(octyloxy)phenylcarbamate Drug Info IC50 = 19 nM [530604]
4-methoxyphenylboronic acid Drug Info IC50 = 2000 nM [529790]
6-fluoropyridin-3-ylboronic acid Drug Info IC50 = 10000 nM [529790]
6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 13 nM [529498]
1-(5-(pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one Drug Info Ki = 18 nM [529594]
2-fluorophenyl 4-(undecyloxy)phenylcarbamate Drug Info IC50 = 15 nM [530604]
2-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate Drug Info IC50 = 7.7 nM [530604]
Propan-2-one O-3-butoxyphenylcarbamoyl oxime Drug Info IC50 = 6300 nM [530604]
Propan-2-one O-4-(octyloxy)phenylcarbamoyl oxime Drug Info IC50 = 2.4 nM [530604]
Propan-2-one O-4-(nonyloxy)phenylcarbamoyl oxime Drug Info IC50 = 2.1 nM [530604]
Cyclopentylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 34 nM [529498]
Cyclobutylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 54 nM [529498]
Propan-2-one O-4-(decyloxy)phenylcarbamoyl oxime Drug Info IC50 = 2.2 nM [530604]
1,1,1-Trifluoro-7-phenylheptan-2-one Drug Info IC50 = 5000 nM [527476]
Furan-2-ylmethylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 175 nM [529498]
Phenethylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 481 nM [529498]
Allylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 696 nM [529498]
Benzaldehyde O-4-methoxyphenylcarbamoyl oxime Drug Info IC50 = 290 nM [530604]
Adamant-1-ylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 4089 nM [529498]
1,1,1-trifluorododecan-2-one Drug Info IC50 = 1800 nM [529157]
2,2-dimethyl-3-methyleneheptadecane Drug Info IC50 = 89 nM [529157]
1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one Drug Info IC50 = 4 nM [529594]
Phenyl 4-(octyloxy)phenylcarbamate Drug Info IC50 = 5.4 nM [530604]
1-(4-chlorooxazol-2-yl)-7-phenylheptan-1-one Drug Info Ki = 4 nM [529603]
8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 5.4 nM [529498]
Phenyl 1-(4-butoxyphenyl)propylcarbamate Drug Info IC50 = 12 nM [530604]
1-(oxazolo[4,5-b]pyridin-2-yl)octan-1-one Drug Info Ki = 0.69 nM [529193]
4-cyanophenyl ethyl dodecylphosphonate Drug Info IC50 = 12 nM [529659]
Benzaldehyde O-4-(pentyloxy)phenylcarbamoyl oxime Drug Info IC50 = 3.5 nM [530604]
N-Hexylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 57 nM [529498]
7-Phenyl-1-(1,3,4-thiadiazol-2-yl)-heptan-1-one Drug Info IC50 = 300 nM [529594]
7-phenyl-1-(4-phenyloxazol-2-yl)heptan-1-one Drug Info Ki = 65 nM [529603]
1-(1,3,4-oxadiazol-2-yl)octadec-9-en-1-one Drug Info Ki = 90 nM [529594]
4-fluorophenyl 4-butoxybenzylcarbamate Drug Info IC50 = 4.6 nM [530604]
Indan-2-ylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 215 nM [529498]
2-fluorophenyl 4-butoxybenzylcarbamate Drug Info IC50 = 9.2 nM [530604]
1-(oxazolo[4,5-b]pyridin-2-yl)pentan-1-one Drug Info Ki = 50 nM [529193]
1-(oxazolo[4,5-b]pyridin-2-yl)dodecan-1-one Drug Info Ki = 0.57 nM [529193]
Methyl 2-(7-phenylheptanoyl)oxazole-4-carboxylate Drug Info Ki = 3.4 nM [529603]
Cyclohexylcarbamic acidbiphenyl-3-yl ester Drug Info IC50 = 63 nM [529498]
1-(4-acetyloxazol-2-yl)-7-phenylheptan-1-one Drug Info Ki = 2 nM [529603]
1-(4-methoxyoxazol-2-yl)-7-phenylheptan-1-one Drug Info Ki = 740 nM [529603]
Phenyl 4-(dodecyloxy)phenylcarbamate Drug Info IC50 = 1.8 nM [530604]
(Z)-1-(benzo[d]oxazol-2-yl)octadec-9-en-1-one Drug Info Ki = 370 nM [529193]
1-(4-iodooxazol-2-yl)-7-phenylheptan-1-one Drug Info Ki = 6.5 nM [529603]
Propan-2-one O-4-butoxyphenylcarbamoyl oxime Drug Info IC50 = 28 nM [530604]
1-(oxazol-2-yl)-7-phenylheptan-1-one Drug Info IC50 = 2500 nM [529603]
Biphenyl-3-ylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 3091 nM [529498]
Benzaldehyde O-4-(decyloxy)phenylcarbamoyl oxime Drug Info IC50 = 0.35 nM [530604]
1-(5-methyloxazol-2-yl)-7-phenylheptan-1-one Drug Info Ki = 80 nM [529193]
7-Phenyl-1-(pyridazin-3-yl)-heptan-1-one Drug Info IC50 = 3000 nM [529594]
3-(trifluoromethyl)phenyl 4-butoxybenzylcarbamate Drug Info IC50 = 40 nM [530604]
Naphthalen-2-yl cyclohexylcarbamate Drug Info IC50 = 324 nM [529791]
Phenyl 4-(hexyloxy)phenylcarbamate Drug Info IC50 = 31 nM [530604]
1-(4-bromooxazol-2-yl)-7-phenylheptan-1-one Drug Info Ki = 3 nM [529603]
Benzaldehyde O-4-(nonyloxy)phenylcarbamoyl oxime Drug Info IC50 = 0.25 nM [530604]
Benzaldehyde O-4-(octyloxy)phenylcarbamoyl oxime Drug Info IC50 = 0.43 nM [530604]
3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 600 nM [529157]
Benzaldehyde O-4-butoxyphenylcarbamoyl oxime Drug Info IC50 = 8.5 nM [530604]
2-fluorophenyl 4-(hexyloxy)phenylcarbamate Drug Info IC50 = 710 nM [530604]
Phenyl 4-(undecyloxy)phenylcarbamate Drug Info IC50 = 1 nM [530604]
7-Phenyl-1-(thiazol-2-yl)-heptan-1-one Drug Info Ki = 800 nM [529594]
Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate Drug Info Ki = 0.9 nM [529594]
Methylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 13901 nM [529498]
1-(5-fluorooxazol-2-yl)-7-phenylheptan-1-one Drug Info Ki = 30 nM [529193]
1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one Drug Info IC50 = 13900 nM [529157]
ARACHIDONYL TRIFLUOROMETHYLKETONE Drug Info IC50 = 3700 nM [530576]
Cyclohexylmethylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 66 nM [529498]
Benzylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 139 nM [529498]
Phenylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 3942 nM [529498]
2-(7-phenylheptanoyl)oxazole-4-carbaldehyde Drug Info Ki = 55 nM [529603]
2-(7-phenylheptanoyl)oxazole-5-carbonitrile Drug Info IC50 = 7 nM [529603]
1-(1,3,4-thiadiazol-2-yl)octadec-9-en-1-one Drug Info Ki = 170 nM [529594]
1,1,1-Trifluoro-undecan-2-one Drug Info IC50 = 10000 nM [527476]
2-fluorophenyl 4-butoxyphenylcarbamate Drug Info IC50 = 340 nM [530604]
1-(5-(furan-2-yl)oxazol-2-yl)octadec-9-en-1-one Drug Info Ki = 54 nM [529594]
Benzaldehyde O-4-(heptyloxy)phenylcarbamoyl oxime Drug Info IC50 = 8.6 nM [530604]
Propofol Drug Info IC50 = 14000 nM [529791]
4-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate Drug Info IC50 = 12 nM [530604]
3-chlorophenyl 4-butoxybenzylcarbamate Drug Info IC50 = 12 nM [530604]
Propan-2-one O-4-(pentyloxy)phenylcarbamoyl oxime Drug Info IC50 = 28 nM [530604]
2-fluorophenyl 4-(decyloxy)phenylcarbamate Drug Info IC50 = 9.2 nM [530604]
Benzaldehyde O-4-ethoxyphenylcarbamoyl oxime Drug Info IC50 = 81 nM [530604]
Nicotinaldehyde O-4-butoxyphenylcarbamoyl oxime Drug Info IC50 = 14 nM [530604]
4-methoxyphenyl 1-(4-butoxyphenyl)propylcarbamate Drug Info IC50 = 12 nM [530604]
2-fluorophenyl 4-phenoxyphenylcarbamate Drug Info IC50 = 1300 nM [530604]
Propan-2-one O-4-propoxyphenylcarbamoyl oxime Drug Info IC50 = 210 nM [530604]
Phenyl 4-(heptyloxy)phenylcarbamate Drug Info IC50 = 8.6 nM [530604]
2-(7-phenylheptanoyl)oxazole-4-carbonitrile Drug Info IC50 = 20 nM [529603]
1-Oxazolo[4,5-b]pyridin-2-yl-octadec-9-yn-1-one Drug Info IC50 = 2 nM [527476]
2-fluorophenyl 4'-ethylbiphenyl-4-ylcarbamate Drug Info IC50 = 810 nM [530604]
4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 9.4 nM [529498]
2-fluorophenyl 4-(heptyloxy)phenylcarbamate Drug Info IC50 = 28 nM [530604]
Nicotinaldehyde O-4-propoxyphenylcarbamoyl oxime Drug Info IC50 = 29 nM [530604]
2-Cyclohexylacetic acidbiphenyl-3-yl ester Drug Info IC50 = 2551 nM [529498]
7-phenyl-1-(5-phenyloxazol-2-yl)heptan-1-one Drug Info IC50 = 80 nM [529594]
1-(1,2,4-Oxadiazol-3-yl)-7-phenylheptan-1-one Drug Info IC50 = 500 nM [529594]
Phenyl 4-(decyloxy)phenylcarbamate Drug Info IC50 = 1.4 nM [530604]
Propan-2-one O-4-ethoxyphenylcarbamoyl oxime Drug Info IC50 = 730 nM [530604]
Pyridin-3-yl 4-butoxybenzylcarbamate Drug Info IC50 = 6.1 nM [530604]
4-Nitrophenyl 4-Benzylpiperazine-1-carboxylate Drug Info IC50 = 930 nM [530654]
Isopropylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 521 nM [529498]
3-(decylthio)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 170 nM [529157]
PHENMEDIPHAM Drug Info IC50 = 77 nM [530469]
2-(7-phenylheptanoyl)oxazole-4-carboxamide Drug Info Ki = 1.6 nM [529603]
PARAOXON Drug Info IC50 = 5900 nM [529440]
Isopropyl dodecylfluorophosphonate Drug Info IC50 = 3 nM [529440]
2-chloro-1-(5-(pyridin-2-yl)oxazol-2-yl)ethanone Drug Info Ki = 800 nM [528884]
Cyclopentyl(5-(pyridin-2-yl)oxazol-2-yl)methanone Drug Info Ki = 2500 nM [528884]
1,1,1-Trifluoro-8-phenyl-octan-2-one Drug Info IC50 = 5000 nM [527476]
1-(5-(pyridin-2-yl)oxazol-2-yl)pentan-1-one Drug Info Ki = 3000 nM [529193]
1-(4-methyloxazol-2-yl)-7-phenylheptan-1-one Drug Info Ki = 520 nM [529603]
BMS-1 Drug Info Ki = 2 nM [529859]
(Z)-2-Methyl-1-oxazol-2-yl-octadec-9-en-1-one Drug Info Ki = 1400 nM [526085]
Propan-2-one O-4-(hexyloxy)phenylcarbamoyl oxime Drug Info IC50 = 18 nM [530604]
(Z)-2,2-Dimethyl-1-oxazol-2-yl-octadec-9-en-1-one Drug Info Ki = 14200 nM [526085]
Dodecane-1-sulfonyl fluoride Drug Info IC50 = 2 nM [529659]
N-(2-iodethyl)arachidonylamide Drug Info IC50 = 10070 nM [529848]
1-(5-(pyridin-2-yl)oxazol-2-yl)octan-1-one Drug Info Ki = 49 nM [529193]
Nicotinaldehyde O-4-ethoxyphenylcarbamoyl oxime Drug Info IC50 = 150 nM [530604]
1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one Drug Info IC50 = 14800 nM [529157]
3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 280 nM [529157]
1,1,1-trifluoro-3-(hexylthio)propan-2-one Drug Info IC50 = 2500 nM [529157]
3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 3000 nM [529157]
1,1,1-trifluoro-3-(octylthio)propan-2-one Drug Info IC50 = 300 nM [529157]
1-(oxazol-2-yl)-3-(4-phenoxyphenyl)propan-1-one Drug Info IC50 = 500 nM [529284]
N-Butylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 113 nM [529498]
4-cyanophenylboronic acid Drug Info IC50 = 290 nM [529790]
N-Octylcarbamic Acid Biphenyl-3-yl Ester Drug Info IC50 = 53 nM [529498]
LY-2318912 Drug Info IC50 = 23 nM [528802]
2-fluorophenylboronic acid Drug Info IC50 = 710 nM [529790]
AR-C70484XX Drug Info IC50 = 59 nM [530576]
3-(biphenyl-4-yl)-1-(oxazol-2-yl)propan-1-one Drug Info IC50 = 180 nM [529284]
References
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Ref 530251J Med Chem. 2009 Dec 10;52(23):7410-20.Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.
Ref 530251J Med Chem. 2009 Dec 10;52(23):7410-20.Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.
Ref 529594J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Ref 529594J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Ref 529594J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Ref 529193Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. Epub 2007 Nov 6.Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Ref 529848Bioorg Med Chem. 2009 Jan 1;17(1):49-56. Epub 2008 Nov 17.Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH.
Ref 529327Bioorg Med Chem Lett. 2008 Mar 15;18(6):2109-13. Epub 2008 Jan 30.Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).
Ref 530576Bioorg Med Chem. 2010 Jan 15;18(2):945-52. Epub 2009 Nov 17.1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amidehydrolase.
Ref 530218Eur J Med Chem. 2009 Oct;44(10):4179-91. Epub 2009 May 22.Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.
Ref 530218Eur J Med Chem. 2009 Oct;44(10):4179-91. Epub 2009 May 22.Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.
Ref 530200Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. Epub 2009 May 29.Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.
Ref 529638Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43. Epub 2008 Jul 25.Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.
Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 529975Eur J Med Chem. 2009 Jul;44(7):2994-3008. Epub 2009 Jan 20.The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.
Ref 529975Eur J Med Chem. 2009 Jul;44(7):2994-3008. Epub 2009 Jan 20.The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.
Ref 529975Eur J Med Chem. 2009 Jul;44(7):2994-3008. Epub 2009 Jan 20.The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 529193Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. Epub 2007 Nov 6.Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Ref 529193Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. Epub 2007 Nov 6.Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Ref 528323J Med Chem. 2006 Jul 27;49(15):4650-6.Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system.
Ref 528323J Med Chem. 2006 Jul 27;49(15):4650-6.Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system.
Ref 529848Bioorg Med Chem. 2009 Jan 1;17(1):49-56. Epub 2008 Nov 17.Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH.
Ref 529440Nat Chem Biol. 2008 Jun;4(6):373-8. Epub 2008 Apr 27.Activation of the endocannabinoid system by organophosphorus nerve agents.
Ref 529603Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. Epub 2008 Jun 28.Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fattyacid amide hydrolase.
Ref 529008J Med Chem. 2007 Oct 4;50(20):5012-23. Epub 2007 Sep 1.Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase.
Ref 529008J Med Chem. 2007 Oct 4;50(20):5012-23. Epub 2007 Sep 1.Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase.
Ref 530527J Med Chem. 2010 Jan 14;53(1):230-40.X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.
Ref 529659Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Epub 2008 Aug 6.Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
Ref 529659Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Epub 2008 Aug 6.Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
Ref 529659Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Epub 2008 Aug 6.Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
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Ref 527476J Med Chem. 2005 Mar 24;48(6):1849-56.Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.
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Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
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Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
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Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
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Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
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Ref 529594J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
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Ref 529498J Med Chem. 2008 Jun 26;51(12):3487-98. Epub 2008 May 29.Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.
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Ref 527476J Med Chem. 2005 Mar 24;48(6):1849-56.Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.
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Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
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Ref 529498J Med Chem. 2008 Jun 26;51(12):3487-98. Epub 2008 May 29.Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.
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Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 529498J Med Chem. 2008 Jun 26;51(12):3487-98. Epub 2008 May 29.Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.
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Ref 529594J Med Chem. 2008 Aug 14;51(15):4392-403. Epub 2008 Jul 16.Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Ref 530604Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. Epub 2009 Nov 24.Oxime carbamate--discovery of a series of novel FAAH inhibitors.
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