| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T73726 | ||||
| Target Name | Fungal Cytochrome P450 51 | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Tioconazole | Drug Info | Ki = 400 nM | [552597] | |
| Ketoconazole | Drug Info | IC50 = 9 nM | [552597] | ||
| ANALOGUE A | Drug Info | IC50 = 300 nM | [528602] | ||
| CP-320626 | Drug Info | IC50 = 4000 nM | [528602] | ||
| References | |||||
| Ref 552597 | Development and validation of an in silico P450 profiler based on pharmacophore models. Curr Drug Discov Technol. 2006 Mar;3(1):1-48. | ||||
| Ref 552597 | Development and validation of an in silico P450 profiler based on pharmacophore models. Curr Drug Discov Technol. 2006 Mar;3(1):1-48. | ||||
| Ref 528602 | Drug Metab Dispos. 2007 Mar;35(3):493-500. Epub 2006 Dec 28.Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. | ||||
| Ref 528602 | Drug Metab Dispos. 2007 Mar;35(3):493-500. Epub 2006 Dec 28.Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. | ||||
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