Target Validation Information
Target ID T78429
Target Name Inhibitor of nuclear factor kappa B kinase beta subunit
Target Type
Clinical Trial
Drug Potency against Target SC-514 Drug Info IC50 = 2000 nM [529039]
4-amino-biphenyl-3-carboxylic acid amide Drug Info IC50 = 14500 nM [528195]
2-amino-5-phenylthiophene-3-carboxamide Drug Info IC50 = 1900 nM [528195]
5-amino-2-phenyl-oxazole-4-carboxylic acid amide Drug Info IC50 = 11000 nM [528195]
5-amino-2-p-tolyl-oxazole-4-carboxylic acid amide Drug Info IC50 = 12700 nM [528195]
3-amino-5-(4-chlorophenyl)thiophene-2-carboxamide Drug Info IC50 = 6600 nM [528195]
6-phenyl-thieno[3,2-d]pyrimidin-4-ylamine Drug Info IC50 = 970 nM [528195]
2-amino-quinoline-3-carboxylic acid amide Drug Info IC50 = 9600 nM [528195]
3-amino-benzo[b]thiophene-2-carboxylic acid amide Drug Info IC50 = 12600 nM [528195]
References
Ref 529039Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.
Ref 528195J Med Chem. 2006 May 18;49(10):2898-908.Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Ref 528195J Med Chem. 2006 May 18;49(10):2898-908.Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Ref 528195J Med Chem. 2006 May 18;49(10):2898-908.Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Ref 528195J Med Chem. 2006 May 18;49(10):2898-908.Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Ref 528195J Med Chem. 2006 May 18;49(10):2898-908.Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Ref 528195J Med Chem. 2006 May 18;49(10):2898-908.Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Ref 528195J Med Chem. 2006 May 18;49(10):2898-908.Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Ref 528195J Med Chem. 2006 May 18;49(10):2898-908.Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.

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