| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T97713 | ||||
| Target Name | Inosine-5'-monophosphate dehydrogenase 1 | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Mycophenolic hydroxamic acid | Drug Info | IC50 = 350 nM | [531203] | |
| Mycophenolic bis(sulfonamide) | Drug Info | Ki = 18200 nM | [529565] | ||
| Tiazofurin adenine dinucleotide | Drug Info | Ki = 100 nM | [529172] | ||
| Azathioprine | Drug Info | IC50 = 500 nM | [552482] | ||
| References | |||||
| Ref 531203 | Bioorg Med Chem. 2010 Nov 15;18(22):8106-11. Epub 2010 Sep 18.Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells amongthe mycophenolic acid derivatives. | ||||
| Ref 529565 | Bioorg Med Chem. 2008 Aug 1;16(15):7462-9. Epub 2008 Jun 10.Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. | ||||
| Ref 529172 | J Med Chem. 2007 Dec 27;50(26):6685-91. Epub 2007 Nov 27.Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. | ||||
| Ref 552482 | AMPA receptor antagonists as potential anticonvulsant drugs. Curr Top Med Chem. 2005;5(1):31-42. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.