| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T81900 | ||||
| Target Name | Insulin-degrading Enzyme | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Bacitracin | Drug Info | IC50 = 400000 nM | [552714] | |
| GNF-PF-4478 | Drug Info | IC50 = 10854 nM | [531262] | ||
| References | |||||
| Ref 552714 | Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5. | ||||
| Ref 531262 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
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