| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T68782 | ||||
| Target Name | Prostaglandin D2 receptor | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | Laropiprant+niacin | Drug Info | IC50 = 0.9~4 nM | [552452] | |
| LAROPIPRANT | Drug Info | IC50 = 4 nM | [528672] | ||
| DIASTEREOMER 2 | Drug Info | Ki = 8.9 nM | [528672] | ||
| References | |||||
| Ref 552452 | Targeting ischemic stroke with a novel opener of ATP-sensitive potassium channels in the brain. Mol Pharmacol. 2004 Nov;66(5):1160-8. Epub 2004 Aug 10. | ||||
| Ref 528672 | J Med Chem. 2007 Feb 22;50(4):794-806.Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). | ||||
| Ref 528672 | J Med Chem. 2007 Feb 22;50(4):794-806.Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). | ||||
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