| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T46360 | ||||
| Target Name | Sigma(1)-type opioid receptor | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Dextromethorphan | Drug Info | IC50 = 2500 nM | [552601] | |
| OPC-14523 | Drug Info | IC50 = 2.3 nM | [552853] | ||
| DITOLYLGUANIDINE | Drug Info | Ki = 60 nM | [533852] | ||
| E-5842 | Drug Info | IC50 > 100000 nM | [552871] | ||
| References | |||||
| Ref 552601 | N-methyl-D-aspartate receptor (NMDA) antagonists as potential pain therapeutics. Curr Top Med Chem. 2006;6(8):749-70. | ||||
| Ref 552853 | 5-HT1 receptor augmentation strategies as enhanced efficacy: therapeutics for psychiatric disorders. Curr Top Med Chem. 2008;8(12):1008-23. | ||||
| Ref 533852 | J Med Chem. 1994 Jun 10;37(12):1737-9.Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells. | ||||
| Ref 552871 | Recent advances in the research of HIV-1 RNase H inhibitors. Mini Rev Med Chem. 2008 Oct;8(12):1243-51. | ||||
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