| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T12119 | ||||
| Target Name | Voltage-gated sodium channel subunit alpha Nav1.7 | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | 4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole | Drug Info | IC50 = 2160 nM | [531103] | |
| 4-(2'-(trifluoromethoxy)biphenyl-3-yl)oxazole | Drug Info | IC50 = 1940 nM | [531103] | ||
| V-102862 | Drug Info | Ki = 360 nM | [531103] | ||
| 4-(2'-(trifluoromethyl)biphenyl-3-yl)oxazole | Drug Info | IC50 = 5310 nM | [531103] | ||
| References | |||||
| Ref 531103 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. Epub 2010 Jul 21.Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. | ||||
| Ref 531103 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. Epub 2010 Jul 21.Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. | ||||
| Ref 531103 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. Epub 2010 Jul 21.Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. | ||||
| Ref 531103 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. Epub 2010 Jul 21.Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. | ||||
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