| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T67022 | ||||
| Target Name | Caspase | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | Ac-DEVD-CHO | Drug Info | IC50 = 59.1 nM | [530969] | |
| Isoquinoline-1,3,4(2H)-trione | Drug Info | IC50 = 386 nM | [528057] | ||
| References | |||||
| Ref 530969 | Eur J Med Chem. 2010 Sep;45(9):3858-63. Epub 2010 May 24.Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. | ||||
| Ref 528057 | J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. | ||||
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