Target Validation Information
Target ID T22658
Target Name Interleukin-8
Target Type
Clinical Trial
Drug Potency against Target 2-(2-(2-chlorophenoxy)phenyl)acetic acid Drug Info IC50 = 500 nM [530235]
2-(2-(2-fluorophenoxy)phenyl)acetic acid Drug Info IC50 = 13 nM [530235]
IBUPROPHEN Drug Info IC50 = 50 nM [530235]
2-(2-(2-chlorophenylamino)phenyl)acetic acid Drug Info IC50 = 400 nM [530235]
2-(2-(2-fluorophenylamino)phenyl)acetic acid Drug Info IC50 = 9 nM [530235]
R-KETOPROFEN Drug Info IC50 = 20 nM [530235]
2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid Drug Info IC50 = 25 nM [530235]
References
Ref 530235Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Ref 530235Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Ref 530235Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Ref 530235Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Ref 530235Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Ref 530235Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Ref 530235Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.

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