Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T22658 | ||||
Target Name | Interleukin-8 | ||||
Target Type | Clinical Trial |
||||
Drug Potency against Target | 2-(2-(2-chlorophenoxy)phenyl)acetic acid | Drug Info | IC50 = 500 nM | [530235] | |
2-(2-(2-fluorophenoxy)phenyl)acetic acid | Drug Info | IC50 = 13 nM | [530235] | ||
IBUPROPHEN | Drug Info | IC50 = 50 nM | [530235] | ||
2-(2-(2-chlorophenylamino)phenyl)acetic acid | Drug Info | IC50 = 400 nM | [530235] | ||
2-(2-(2-fluorophenylamino)phenyl)acetic acid | Drug Info | IC50 = 9 nM | [530235] | ||
R-KETOPROFEN | Drug Info | IC50 = 20 nM | [530235] | ||
2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid | Drug Info | IC50 = 25 nM | [530235] | ||
References | |||||
Ref 530235 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. | ||||
Ref 530235 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. | ||||
Ref 530235 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. | ||||
Ref 530235 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. | ||||
Ref 530235 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. | ||||
Ref 530235 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. | ||||
Ref 530235 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. Epub 2009 Jun 13.Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. |
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