Target Validation Information
Target ID T90553
Target Name MARK3
Target Type
Clinical Trial
Drug Potency against Target UCN-01 Drug Info IC50 = 27 nM [552220]
Action against Disease Model UCN-01 Abrogated DNA damage-induced G2 arrest, leading to mitotic entry and subsequent cell death. [537564] Drug Info
The Effect of Target Knockout, Knockdown or Genetic Variations Tau?knockout mice show behavioural impairments and structural abnormalities with advancing age,suggesting that long?term suppression of tau as a therapy for tauopathies might befraught with complications [552220]
References
Ref 552220The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res. 2000 Apr 15;60(8):2108-12.
Ref 537564Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.

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