| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T98269 | ||||
| Target Name | Interleukin-1 beta convertase | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | L-709049 | Drug Info | Ki = 9 nM | [531052] | |
| PRALNACASAN | Drug Info | IC50 = 3.6 nM | [528340] | ||
| Z-VAD-CHO | Drug Info | Ki = 8 nM | [527847] | ||
| Z-YVAD-CHO | Drug Info | Ki = 180 nM | [527847] | ||
| References | |||||
| Ref 531052 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5184-90. Epub 2010 Jul 8.Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1). | ||||
| Ref 528340 | Bioorg Med Chem Lett. 2006 Sep 15;16(18):4728-32. Epub 2006 Jul 25.Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors. | ||||
| Ref 527847 | Bioorg Med Chem Lett. 2006 Feb;16(3):559-62. Epub 2005 Nov 4.Tethering identifies fragment that yields potent inhibitors of human caspase-1. | ||||
| Ref 527847 | Bioorg Med Chem Lett. 2006 Feb;16(3):559-62. Epub 2005 Nov 4.Tethering identifies fragment that yields potent inhibitors of human caspase-1. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.