Target Validation Information
Target ID T57943
Target Name Apopain
Target Type
Research
Drug Potency against Target 5-(azepan-1-ylsulfonyl)indoline-2,3-dione Drug Info IC50 = 1900 nM [530274]
5-(piperidin-1-ylsulfonyl)indoline-2,3-dione Drug Info IC50 = 2200 nM [530274]
5-(azetidin-1-ylsulfonyl)indoline-2,3-dione Drug Info IC50 = 170 nM [530274]
2-methylisoquinoline-1,3,4-trione Drug Info IC50 = 255 nM [528057]
Ac-Asp-Glu-Val-Asp-CHO Drug Info Ki = 3.2 nM [527329]
PRALNACASAN Drug Info IC50 = 1300 nM [528340]
Ac-DEVD-CHO Drug Info IC50 = 1.6 nM [530969]
Isoquinoline-1,3,4(2H)-trione Drug Info IC50 = 149 nM [528057]
2-allylisoquinoline-1,3,4-trione Drug Info IC50 = 261 nM [528057]
2-(4-fluoro-benzyl)isoquinoline-1,3,4-trione Drug Info IC50 = 630 nM [528057]
2-phenethylisoquinoline-1,3,4-trione Drug Info IC50 = 544 nM [528057]
5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione Drug Info IC50 = 2800 nM [530274]
2-(4-methoxy-benzyl)isoquinoline-1,3,4-trione Drug Info IC50 = 4630 nM [528057]
2-benzylisoquinoline-1,3,4-trione Drug Info IC50 = 331 nM [528057]
References
Ref 530274Bioorg Med Chem. 2009 Aug 15;17(16):6040-7. Epub 2009 Jul 7.Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach.
Ref 530274Bioorg Med Chem. 2009 Aug 15;17(16):6040-7. Epub 2009 Jul 7.Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach.
Ref 530274Bioorg Med Chem. 2009 Aug 15;17(16):6040-7. Epub 2009 Jul 7.Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach.
Ref 528057J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Ref 527329J Med Chem. 2004 Dec 16;47(26):6455-8.Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3.
Ref 528340Bioorg Med Chem Lett. 2006 Sep 15;16(18):4728-32. Epub 2006 Jul 25.Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors.
Ref 530969Eur J Med Chem. 2010 Sep;45(9):3858-63. Epub 2010 May 24.Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study.
Ref 528057J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Ref 528057J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Ref 528057J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Ref 528057J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Ref 530274Bioorg Med Chem. 2009 Aug 15;17(16):6040-7. Epub 2009 Jul 7.Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach.
Ref 528057J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Ref 528057J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.