Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T92640 | ||||
Target Name | Lysophosphatidic acid receptor Edg-2 | ||||
Target Type | Clinical Trial |
||||
Drug Potency against Target | Dodecyl-phosphonic acid | Drug Info | IC50 = 2638 nM | [527648] | |
Phosphoric acid mono-((E)-tetradec-11-enyl) ester | Drug Info | Ki = 457 nM | [527648] | ||
Phosphoric acid mono-((E)-dec-4-enyl) ester | Drug Info | IC50 = 1300 nM | [527648] | ||
Tetradecyl-phosphonic acid | Drug Info | IC50 = 9674 nM | [527648] | ||
Thiophosphoric acid decyl ester | Drug Info | IC50 = 1220 nM | [527648] | ||
Decyl-phosphonic acid | Drug Info | IC50 = 3122 nM | [527648] | ||
Phosphoric acid mono-((E)-tetradec-9-enyl) ester | Drug Info | Ki = 1146 nM | [527648] | ||
Thiophosphoric acid (E)-dodec-9-enyl ester | Drug Info | IC50 = 2972 nM | [527648] | ||
Phosphoric acid monododecyl ester | Drug Info | Ki = 1354 nM | [527648] | ||
(1,1-Difluoro-pentadecyl)-phosphonic acid | Drug Info | Ki = 788 nM | [527648] | ||
Thiophosphoric acid dec-9-enyl ester | Drug Info | IC50 = 1000 nM | [527648] | ||
Thiophosphoric acid dodecyl ester | Drug Info | IC50 = 2838 nM | [527648] | ||
Phosphoric acid mono-((E)-dodec-9-enyl) ester | Drug Info | IC50 = 916 nM | [527648] | ||
Phosphoric acid monotetradecyl ester | Drug Info | Ki = 1082 nM | [527648] | ||
Thiophosphoric acid (E)-tetradec-9-enyl ester | Drug Info | IC50 = 938 nM | [527648] | ||
Phosphoric acid monodec-9-enyl ester | Drug Info | IC50 = 1510 nM | [527648] | ||
References | |||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. | ||||
Ref 527648 | J Med Chem. 2005 Jul 28;48(15):4919-30.Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. |
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