Target Validation Information
Target ID T65291
Target Name Aldehyde dehydrogenase
Target Type
Successful
Drug Potency against Target Disulfiram Drug Info IC50 = 7.5+/-1.2 microM [553201]
Aloe-emodin Drug Info IC50 = 6000 nM
References
Ref 553201S-methyl N,N-diethylthiocarbamate sulfone, a potential metabolite of disulfiram and potent inhibitor of low Km mitochondrial aldehyde dehydrogenase. Biochem Pharmacol. 1995 Mar 1;49(5):693-700.

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