| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T26617 | ||||
| Target Name | Lactase-phlorizin hydrolase | ||||
| Target Type | Research |
||||
| Drug Potency against Target | 2,5-dideoxy-2,5-imino-dl-glycero-D-manno-heptitol | Drug Info | IC50 = 4000 nM | [534633] | |
| Hyacinthacine B3 | Drug Info | IC50 = 18000 nM | [526494] | ||
| 2,5-dideoxy-2,5-imino-D-altritol | Drug Info | IC50 = 7200 nM | [530905] | ||
| References | |||||
| Ref 534633 | J Nat Prod. 1998 May;61(5):625-8.Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis. | ||||
| Ref 526494 | J Nat Prod. 2002 Dec;65(12):1875-81.New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. | ||||
| Ref 530905 | Bioorg Med Chem. 2010 Jun 1;18(11):3790-4. Epub 2010 Apr 21.2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. | ||||
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