| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T50547 | ||||
| Target Name | Plasmepsin 1 | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | L-mannitol derivative | Drug Info | Ki = 478 nM | [527739] | |
| PS-777621 | Drug Info | Ki = 727 nM | [528560] | ||
| SC-5003 | Drug Info | IC50 = 500 nM | [525693] | ||
| KNI-10006 | Drug Info | IC50 = 280 nM | [530280] | ||
| References | |||||
| Ref 527739 | J Med Chem. 2005 Sep 22;48(19):6090-106.Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. | ||||
| Ref 528560 | J Med Chem. 2006 Dec 14;49(25):7440-9.High antiplasmodial activity of novel plasmepsins I and II inhibitors. | ||||
| Ref 525693 | J Med Chem. 2000 Feb 10;43(3):305-41.Protease inhibitors: current status and future prospects. | ||||
| Ref 530280 | Bioorg Med Chem. 2009 Aug 15;17(16):5933-49. Epub 2009 Jul 3.alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.