Target Validation Information
Target ID T00663
Target Name Mitogen-activated protein kinase 10
Target Type
Research
Drug Potency against Target Phenyl-(3-phenyl-1H-indazol-6-yl)-amine Drug Info IC50 = 48 nM [527722]
N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide Drug Info Ki = 520 nM [528237]
N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide Drug Info Ki = 3300 nM [528237]
AS-601245 Drug Info IC50 = 70 nM [529213]
References
Ref 527722Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9.Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3.
Ref 528237J Med Chem. 2006 Jun 15;49(12):3563-80.Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Ref 528237J Med Chem. 2006 Jun 15;49(12):3563-80.Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Ref 529213Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.