| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T94400 | ||||
| Target Name | Thymidine monophosphate kinase | ||||
| Target Type | Research |
||||
| Drug Potency against Target | CHLORODEOXYURIDINE | Drug Info | Ki = 10000 nM | [529464] | |
| BROMODEOXYURIDINE | Drug Info | Ki = 5000 nM | [529464] | ||
| 5'-amino-5'-deoxy-alpha-D-thymidine | Drug Info | Ki = 16000 nM | [529076] | ||
| References | |||||
| Ref 529464 | Bioorg Med Chem. 2008 Jun 1;16(11):6075-85. Epub 2008 Apr 25.Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity. | ||||
| Ref 529464 | Bioorg Med Chem. 2008 Jun 1;16(11):6075-85. Epub 2008 Apr 25.Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity. | ||||
| Ref 529076 | J Med Chem. 2007 Nov 1;50(22):5281-92. Epub 2007 Oct 2.Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth. | ||||
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