Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T03755 Target Info
Target Name Apoptosis regulator Bcl-W (BCL-W)
Synonyms
KIAA0271; Bcl2-L-2; Bcl-2-like protein 2; BCLW
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Target Type Clinical trial Target
Gene Name BCL2L2
Biochemical Class B-cell lymphoma Bcl-2
UniProt ID
B2CL2_HUMAN
Co-Targets of This Target  Top
Co-Target Name Apoptosis regulator Bcl-2 (BCL-2) Successful Target
UniProt ID BCL2_HUMAN
Gene Name BCL2
Synonyms
Bcl-2
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Representative Drug(s) ABT-263 Drug Info Ki < 0.01 nM [1]
Co-Target Name Apoptosis regulator Bcl-xL (BCL-xL) Clinical trial Target
UniProt ID B2CL1_HUMAN
Gene Name BCL2L1
Synonyms
Bcl2like protein 1; Bcl2L1; Bcl2-L-1; Bcl-XL; Bcl-2-like protein 1; BCLX; BCL2L; Apoptosis regulator Bcl-X
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Representative Drug(s) ABT-263 Drug Info Ki = 0.055 nM [2]
Co-Target Name Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) Clinical trial Target
UniProt ID MCL1_HUMAN
Gene Name MCL1
Synonyms
mcl1/EAT; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; Bcl-2-like protein 3; BCL2L3
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Representative Drug(s) ABT-263 Drug Info Ki < 1 nM [3]
Co-Target Name Bcl2-antagonist of cell death (BAD) Co-Target
UniProt ID BAD_HUMAN
Gene Name BAD
Synonyms
Bcl2-associated agonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death
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Representative Drug(s) ABT-263 Drug Info Ki < 0.5 nM [4]
Co-Target Name Bcl-2-like protein 1-Bcl-2-like protein 11 complex Co-Target
UniProt ID B2CL1_HUMAN-B2L11_HUMAN
Gene Name BCL2L1-BCL2L11
Representative Drug(s) ABT-263 Drug Info IC50 = 4.3 nM [5]
References  Top
REF 1 Clinical candidates modulating protein-protein interactions: The fragment-based experience. Eur J Med Chem. 2019 Apr 1;167:76-95.
REF 2 Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection. J Med Chem. 2018 Apr 12;61(7):2636-51.
REF 3 The chemical biology of apoptosis: Revisited after 17 years. Eur J Med Chem. 2019 Sep 1;177:63-75.
REF 4 Recent developments in fragment-based drug discovery. J Med Chem. 2008 Jul 10;51(13):3661-80.
REF 5 Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors. Eur J Med Chem. 2015 Jan 27;90:315-331.

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