Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T03896 Target Info
Target Name Hepatitis C virus Serine protease NS3/4A (HCV NS3/4A)
Synonyms
HCV Hepacivirin/NS4A; HCV NS3P/NS4A; HCV p70/NS4A
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Target Type Successful Target
Gene Name HCV NS3/4A
UniProt ID
POLG_HCV1
Co-Targets of This Target  Top
Co-Target Name Pancreatic elastase 1 (CELA1) Successful Target
UniProt ID CELA1_HUMAN
Gene Name CELA1
Synonyms
Elastase; CELA1
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Representative Drug(s) Drug Info IC50 = 30 nM [1]
Co-Target Name Coagulation factor IIa (F2) Successful Target
UniProt ID THRB_HUMAN
Gene Name F2
Synonyms
Prothrombin; Coagulation factor II
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Representative Drug(s) Drug Info IC50 < 1000 nM Click to Show More [2]
2 Drug Info IC50 < 1000 nM [2]
Co-Target Name Chymase (CYM) Clinical trial Target
UniProt ID CMA1_HUMAN
Gene Name CMA1
Synonyms
Mast cell protease I; CYH; Alpha-chymase
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Representative Drug(s) Drug Info IC50 = 26 nM Click to Show More [1]
2 Drug Info IC50 = 32 nM [1]
Co-Target Name Cathepsin K (CTSK) Clinical trial Target
UniProt ID CATK_HUMAN
Gene Name CTSK
Synonyms
Cathepsin X; Cathepsin O2; Cathepsin O; CTSO2; CTSO
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Representative Drug(s) Drug Info IC50 = 40 nM Click to Show More [1]
2 Drug Info IC50 = 630 nM [1]
Co-Target Name Cathepsin S (CTSS) Clinical trial Target
UniProt ID CATS_HUMAN
Gene Name CTSS
Synonyms
Cysteine protease cathepsin S
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Representative Drug(s) Drug Info IC50 = 120 nM Click to Show More [1]
2 Drug Info IC50 = 300 nM [1]
3 Simeprevir Drug Info IC50 = 800 nM [4]
Co-Target Name Neutrophil elastase (NE) Clinical trial Target
UniProt ID ELNE_HUMAN
Gene Name ELANE
Synonyms
PMN elastase; Medullasin; Human leukocyte elastase; HLE; Elastase-2; ELA2; Bone marrow serine protease
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Representative Drug(s) Drug Info IC50 = 680 nM [3]
Co-Target Name Cathepsin L (CTSL) Clinical trial Target
UniProt ID CATL1_HUMAN
Gene Name CTSL
Synonyms
Major excreted protein; MEP; Cathepsin L1; CTSL1
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Representative Drug(s) Drug Info IC50 = 760 nM [1]
Co-Target Name Cathepsin V (CTSV) Patented-recorded Target
UniProt ID CATL2_HUMAN
Gene Name CTSV
Synonyms
UNQ268/PRO305; Cathepsin U; Cathepsin L2; CTSU; CTSL2; CATL2
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Representative Drug(s) Drug Info IC50 = 75 nM [1]
Co-Target Name Cathepsin B (CTSB) Patented-recorded Target
UniProt ID CATB_HUMAN
Gene Name CTSB
Synonyms
Ctsb; Cathepsins B; Cathepsin-B; Cathepsin B1; CPSB; APPS; APP secretase
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Representative Drug(s) Drug Info IC50 = 210 nM [5]
References  Top
REF 1 MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrob Agents Chemother. 2010 Jan;54(1):305-11.
REF 2 Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6325-30.
REF 3 Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease. Antimicrob Agents Chemother. 2010 Nov;54(11):4611-8.
REF 4 In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor. Antimicrob Agents Chemother. 2009 Apr;53(4):1377-85.
REF 5 Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem. 2011 Apr 28;54(8):2529-91.

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