Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T05089 | Target Info | |||
Target Name | Calcium-dependent chloride channel anoctamin (ANO) | ||||
Synonyms |
Tumoramplified and overexpressed sequence 2; Tumor-amplified and overexpressed sequence 2; Transmembrane protein 16A; TMEM16A; TAOS2; Oral cancer overexpressed protein 2; ORAOV2; Discovered on gastrointestinal stromal tumors protein 1; DOG1; Anoctamin1; Anoctamin-1
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Target Type | Successful Target | ||||
Gene Name | ANO1 | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | S-mephenytoin 4-hydroxylase (CYP2C9) | Successful Target | ||||
UniProt ID | CP2C9_HUMAN | |||||
Gene Name | CYP2C9 | |||||
Synonyms |
Cytochrome P450 PB-1; Cytochrome P450 MP-8; Cytochrome P450 MP-4; Cytochrome P450 2C9; Cytochrome P-450MP; Cholesterol 25-hydroxylase; CYPIIC9; CYP2C10; (S)-limonene 7-monooxygenase; (S)-limonene 6-monooxygenase; (R)-limonene 6-monooxygenase
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Representative Drug(s) | Drug Info | Ki = 19 nM | [1] | |||
Co-Target Name | Urate anion exchanger 1 (URAT1) | Successful Target | ||||
UniProt ID | S22AC_HUMAN | |||||
Gene Name | SLC22A12 | |||||
Synonyms |
UNQ6453/PRO34004; Solute carrier family 22 member 12; Renal-specific transporter; RST; Organic anion transporter 4-like protein; OATL4
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Representative Drug(s) | Drug Info | IC50 = 22 nM | [2] | |||
Co-Target Name | Multidrug resistance-associated protein 1 (ABCC1) | Successful Target | ||||
UniProt ID | MRP1_HUMAN | |||||
Gene Name | ABCC1 | |||||
Synonyms |
MRP1; MRP; Leukotriene C(4) transporter; LTC4 transporter; ATP-binding cassette sub-family C member 1
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Representative Drug(s) | Drug Info | Ki = 190 nM | [3] | |||
Co-Target Name | Aldo-keto reductase family 1 member C1 (AK1C1_HUMAN) | Co-Target | ||||
UniProt ID | AK1C1_HUMAN | |||||
Gene Name | AKR1C1 | |||||
Synonyms |
20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Dihydrodiol dehydrogenase 1; DD1; Chlordecone reductase homolog HAKRC; High-affinity hepatic bile acid-binding protein; HBAB
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Representative Drug(s) | Drug Info | IC50 = 48 nM | [4] |
References | Top | ||||
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REF 1 | Charge and substituent effects on affinity and metabolism of benzbromarone-based CYP2C19 inhibitors. J Med Chem. 2004 Dec 30;47(27):6768-76. | ||||
REF 2 | The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout. Medchemcomm. 2016;7:1587-95. | ||||
REF 3 | Molecular docking studies and in vitro screening of new dihydropyridine derivatives as human MRP1 inhibitors. Bioorg Med Chem. 2011 May 15;19(10):3249-54. | ||||
REF 4 | Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20... J Med Chem. 2009 May 28;52(10):3259-64. |
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