Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T05090 | Target Info | |||
| Target Name | Histone deacetylase 3 (HDAC3) | ||||
| Synonyms |
SMAP45; RPD32; RPD3-2; HD3
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| Target Type | Clinical trial Target | ||||
| Gene Name | HDAC3 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Histone deacetylase 1 (HDAC1) | Successful Target | ||||
| UniProt ID | HDAC1_HUMAN | |||||
| Gene Name | HDAC1 | |||||
| Synonyms |
RPD3L1; HD1
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| Representative Drug(s) | CHR-3996 | Drug Info | IC50 = 3 nM | [1] | ||
| Co-Target Name | Histone deacetylase 2 (HDAC2) | Clinical trial Target | ||||
| UniProt ID | HDAC2_HUMAN | |||||
| Gene Name | HDAC2 | |||||
| Synonyms |
HD2
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| Representative Drug(s) | CHR-3996 | Drug Info | IC50 = 4 nM | [1] | ||
| Co-Target Name | Histone deacetylase 5 (HDAC5) | Patented-recorded Target | ||||
| UniProt ID | HDAC5_HUMAN | |||||
| Gene Name | HDAC5 | |||||
| Synonyms |
KIAA0600; HD5; Antigen NY-CO-9
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| Representative Drug(s) | CHR-3996 | Drug Info | IC50 = 200 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor. J Med Chem. 2010 Dec 23;53(24):8663-78. | ||||
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