Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T30081 | Target Info | |||
| Target Name | Thymidine kinase 1 (TK1) | ||||
| Synonyms |
Thymidine kinase, cytosolic
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| Target Type | Successful Target | ||||
| Gene Name | TK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Platelet-activating factor acetylhydrolase (PLA2G7) | Clinical trial Target | ||||
| UniProt ID | PAFA_HUMAN | |||||
| Gene Name | PLA2G7 | |||||
| Synonyms |
gVIIA-PLA2; PAFAH; PAF acetylhydrolase; PAF 2-acylhydrolase; Lipoprotein-associated phospholipase A2; LDL-associated phospholipase A2; LDL-PLA(2); Group-VIIA phospholipase A2; 2-acetyl-1-alkylglycerophosphocholine esterase; 1-alkyl-2-acetylglycerophosphocholine esterase
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| Representative Drug(s) | Rilapladib | Drug Info | IC50 = 0.2512 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA. ACS Med Chem Lett. 2016 Nov 15;8(1):43-8. | ||||
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