Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T30653 | Target Info | |||
| Target Name | Acetyl-CoA:lyso-PAF acetyltransferase (PCAT) | ||||
| Synonyms |
Lysophosphatidylcholine acyltransferase; LysoPC acyltransferase; LysoPAFAT; Lyso-PAF acetyltransferase; LPCAT; LPC acyltransferase; Acyltransferase-like; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; AYTL; 1-alkylglycerophosphocholine O-acetyltransferase; 1-acylglycerophosphocholine O-acyltransferase
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| Target Type | Successful Target | ||||
| Gene Name | LPCAT1; LPCAT2 | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
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| Co-Target Name | Aldose reductase (AKR1B1) | Successful Target | ||||
| UniProt ID | ALDR_HUMAN | |||||
| Gene Name | AKR1B1 | |||||
| Synonyms |
Aldehyde reductase; AKR1B1
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 1.05 ug.mL-1 | Click to Show More | [1] | |
| 2 | B-Lactams | Drug Info | IC50 = 600 nM | [17] | ||
| Co-Target Name | Prostaglandin G/H synthase 2 (COX-2) | Successful Target | ||||
| UniProt ID | PGH2_HUMAN | |||||
| Gene Name | PTGS2 | |||||
| Synonyms |
Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PHS II; PGHS-2; PGH synthase 2; Cyclooxygenase-2; COX2; COX-2
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| Representative Drug(s) | B-Lactams | Drug Info | IC50 = 2.5 ug.mL-1 | [2] | ||
| Co-Target Name | Influenza Neuraminidase (Influ NA) | Successful Target | ||||
| UniProt ID | NRAM_I33A0 | |||||
| Gene Name | Influ NA | |||||
| Synonyms |
STNA; NEU1; NANase; N-acylneuraminate glycohydrolase; Influ Sialidase
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| Representative Drug(s) | B-Lactams | Drug Info | IC50 = 9.65 ug.mL-1 | Click to Show More | [3] | |
| 2 | Quercetin | Drug Info | IC50 = 17.65 ug.mL-1 | [3] | ||
| Co-Target Name | LCK tyrosine protein kinase (LCK) | Successful Target | ||||
| UniProt ID | LCK_HUMAN | |||||
| Gene Name | LCK | |||||
| Synonyms |
p56-LCK; Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; Lymphocyte cell-specific protein-tyrosine kinase; Leukocyte C-terminal Src kinase; LSK; LCK p59-Fyn; LCK Protooncogene Syn
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| Representative Drug(s) | B-Lactams | Drug Info | IC50 = 10 ug.mL-1 | Click to Show More | [4] | |
| 2 | Quercetin | Drug Info | IC50 = 40 ug.mL-1 | [4] | ||
| Co-Target Name | Aromatase (CYP19A1) | Successful Target | ||||
| UniProt ID | CP19A_HUMAN | |||||
| Gene Name | CYP19A1 | |||||
| Synonyms |
P-450AROM; Estrogen synthetase; Estrogen synthase; Cytochrome P450 19A1; Cytochrome P-450AROM; CYPXIX; CYP19; CYAR; ARO1
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 12 nM | [5] | ||
| Co-Target Name | Plasmodium Enoyl-ACP reductase (Malaria fabI) | Successful Target | ||||
| UniProt ID | Q965D5_PLAFA | |||||
| Gene Name | Malaria fabI | |||||
| Synonyms |
fabI; NADH-dependent enoyl-ACP reductase; Enoyl-acyl-carrier protein reductase; Enoyl-acyl carrier reductase; Enoyl-acyl carrier protein reductase; Enoyl-ACP reductase FabI
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| Representative Drug(s) | Quercetin | Drug Info | Ki = 22 nM | [6] | ||
| Co-Target Name | ATP-binding cassette transporter G2 (ABCG2) | Successful Target | ||||
| UniProt ID | ABCG2_HUMAN | |||||
| Gene Name | ABCG2 | |||||
| Synonyms |
Urate exporter; Placenta-specific ATP-binding cassette transporter; Mitoxantrone resistance-associated protein; MXR; CDw338; CD338; Breast cancer resistance protein; BCRP1; BCRP; ABCP
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| Representative Drug(s) | Quercetin | Drug Info | EC50 = 30 nM | [7] | ||
| Co-Target Name | Carbonic anhydrase XII (CA-XII) | Successful Target | ||||
| UniProt ID | CAH12_HUMAN | |||||
| Gene Name | CA12 | |||||
| Synonyms |
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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| Representative Drug(s) | B-Lactams | Drug Info | Ki = 60.3 nM | [8] | ||
| Co-Target Name | Arachidonate 5-lipoxygenase (5-LOX) | Successful Target | ||||
| UniProt ID | LOX5_HUMAN | |||||
| Gene Name | ALOX5 | |||||
| Synonyms |
LOG5; 5-lipoxygenase; 5-LO
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| Representative Drug(s) | Quercetin | Drug Info | EC50 ~ 100 mg kg-1 | [9] | ||
| Co-Target Name | Dipeptidyl peptidase 4 (DPP-4) | Successful Target | ||||
| UniProt ID | DPP4_HUMAN | |||||
| Gene Name | DPP4 | |||||
| Synonyms |
Tcell activation antigen CD26; TP103; T-cell activation antigen CD26; Dipeptidyl peptidase IV; Dipeptidyl peptidase 4 soluble form; DPP-IV; DPP IV; DPP 4; CD26; Adenosine deaminase complexing protein-2; Adenosine deaminase complexing protein 2; ADCP2; ADCP-2; ADABP
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| Representative Drug(s) | B-Lactams | Drug Info | IC50 = 120 nM | [10] | ||
| Co-Target Name | Proto-oncogene c-Src (SRC) | Successful Target | ||||
| UniProt ID | SRC_HUMAN | |||||
| Gene Name | SRC | |||||
| Synonyms |
pp60c-src; Tyrosine kinase (pp60(src)); Src tyrosine kinase; SRC1; Proto-oncogene tyrosine-protein kinase Src; Pp60(src); P60-Src; C-src TK; C-Src
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 120 nM | [11] | ||
| Co-Target Name | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Successful Target | ||||
| UniProt ID | POL_HV1B1 | |||||
| Gene Name | HIV RT | |||||
| Synonyms |
HIV p66 RT; HIV Exoribonuclease H
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| Representative Drug(s) | Quercetin | Drug Info | IC50 < 200 ug.mL-1 | [12] | ||
| Co-Target Name | Vascular endothelial growth factor receptor 2 (KDR) | Successful Target | ||||
| UniProt ID | VGFR2_HUMAN | |||||
| Gene Name | KDR | |||||
| Synonyms |
VEGFR2; VEGFR-2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; Fetal liver kinase 1; FLK1; FLK-1; CD309
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 280 nM | [11] | ||
| Co-Target Name | Xanthine dehydrogenase/oxidase (XDH) | Successful Target | ||||
| UniProt ID | XDH_HUMAN | |||||
| Gene Name | XDH | |||||
| Synonyms |
Xanthine oxidase; Xanthine dehydrogenase; XDHA
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| Representative Drug(s) | Quercetin | Drug Info | Ki = 280 nM | Click to Show More | [13] | |
| 2 | B-Lactams | Drug Info | IC50 = 550 nM | [15] | ||
| Co-Target Name | Carbonic anhydrase IV (CA-IV) | Successful Target | ||||
| UniProt ID | CAH4_HUMAN | |||||
| Gene Name | CA4 | |||||
| Synonyms |
Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV
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| Representative Drug(s) | B-Lactams | Drug Info | Ki = 293 nM | [8] | ||
| Co-Target Name | Insulin-like growth factor I receptor (IGF1R) | Successful Target | ||||
| UniProt ID | IGF1R_HUMAN | |||||
| Gene Name | IGF1R | |||||
| Synonyms |
Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 300 nM | [11] | ||
| Co-Target Name | Human immunodeficiency virus Protease (HIV PR) | Successful Target | ||||
| UniProt ID | POL_HV1B1 | |||||
| Gene Name | HIV PR | |||||
| Synonyms |
HIV Retropepsin; HIV PR
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| Representative Drug(s) | B-Lactams | Drug Info | IC50 = 450 nM | Click to Show More | [14] | |
| 2 | Quercetin | Drug Info | IC50 = 600 nM | [14] | ||
| Co-Target Name | Proto-oncogene c-Met (MET) | Successful Target | ||||
| UniProt ID | MET_HUMAN | |||||
| Gene Name | MET | |||||
| Synonyms |
Tyrosine-protein kinase Met; Scatter factor receptor; SF receptor; Met proto-oncogene tyrosine kinase; Hepatocyte growth factor receptor; HGF/SF receptor; HGF-SF receptor; HGF receptor; C-met; C-Met receptor tyrosine kinase
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 580 nM | [11] | ||
| Co-Target Name | Fms-like tyrosine kinase 3 (FLT-3) | Successful Target | ||||
| UniProt ID | FLT3_HUMAN | |||||
| Gene Name | FLT3 | |||||
| Synonyms |
Stem cell tyrosine kinase 1; STK1; STK-1; Receptor-type tyrosine-protein kinase FLT3; Fetal liver kinase-2; FLT-3; FLK2; FLK-2; FL cytokine receptor; CD135
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 590 nM | Click to Show More | [16] | |
| 2 | B-Lactams | Drug Info | IC50 = 830 nM | [16] | ||
| Co-Target Name | Glycogen synthase kinase-3 alpha (GSK-3A) | Successful Target | ||||
| UniProt ID | GSK3A_HUMAN | |||||
| Gene Name | GSK3A | |||||
| Synonyms |
Serine/threonineprotein kinase GSK3A; Serine/threonine-protein kinase GSK3A; Glycogen synthase kinase3 alpha; Glycogen synthase kinase 3; GSK3 alpha; GSK-3 alpha; GSK-3
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| Representative Drug(s) | B-Lactams | Drug Info | IC50 = 800 nM | [18] | ||
| Co-Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | ||||
| UniProt ID | EGFR_HUMAN | |||||
| Gene Name | EGFR | |||||
| Synonyms |
Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 900 nM | [19] | ||
| Co-Target Name | Tyrosine-protein kinase UFO (AXL) | Successful Target | ||||
| UniProt ID | UFO_HUMAN | |||||
| Gene Name | AXL | |||||
| Synonyms |
UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 960 nM | [11] | ||
| Co-Target Name | Lysosomal alpha-glucosidase (GAA) | Successful Target | ||||
| UniProt ID | LYAG_HUMAN | |||||
| Gene Name | GAA | |||||
| Synonyms |
GAA; Aglucosidase alfa; Acid maltase
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| Representative Drug(s) | B-Lactams | Drug Info | IC50 = 5.96 ug.mL-1 | [20] | ||
| Co-Target Name | DNA topoisomerase II alpha (TOP2A) | Clinical trial Target | ||||
| UniProt ID | TOP2A_HUMAN | |||||
| Gene Name | TOP2A | |||||
| Synonyms |
DNA topoisomerase II, alpha isozyme; DNA topoisomerase 2alpha; DNA topoisomerase 2-alpha
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 6.9 ug.mL-1 | [21] | ||
| Co-Target Name | Cytochrome P450 1B1 (CYP1B1) | Clinical trial Target | ||||
| UniProt ID | CP1B1_HUMAN | |||||
| Gene Name | CYP1B1 | |||||
| Synonyms |
CYPIB1
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| Representative Drug(s) | Quercetin | Drug Info | Ki = 23 nM | Click to Show More | [22] | |
| 2 | B-Lactams | Drug Info | Ki = 56 nM | [22] | ||
| Co-Target Name | Serine/threonine-protein kinase pim-1 (PIM1) | Clinical trial Target | ||||
| UniProt ID | PIM1_HUMAN | |||||
| Gene Name | PIM1 | |||||
| Synonyms |
Pim-1 proto-oncogene, serine/threonine kinase; PIM
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 43 nM | [23] | ||
| Co-Target Name | Cyclin-dependent kinase 1 (CDK1) | Clinical trial Target | ||||
| UniProt ID | CDK1_HUMAN | |||||
| Gene Name | CDK1 | |||||
| Synonyms |
P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 450 nM | [24] | ||
| Co-Target Name | Casein kinase II (CSNK2) | Clinical trial Target | ||||
| UniProt ID | CSK21_HUMAN; CSK22_HUMAN; CSK23_HUMAN; CSK2B_HUMAN | |||||
| Gene Name | NO-GeName | |||||
| Representative Drug(s) | B-Lactams | Drug Info | IC50 = 500 nM | Click to Show More | [25] | |
| 2 | Quercetin | Drug Info | IC50 = 550 nM | [25] | ||
| 3 | Quercetin | Drug Info | IC50 = 550 nM | [26] | ||
| 4 | B-Lactams | Drug Info | IC50 < 1000 nM | [30] | ||
| Co-Target Name | NADPH oxidase 4 (NOX4) | Clinical trial Target | ||||
| UniProt ID | NOX4_HUMAN | |||||
| Gene Name | NOX4 | |||||
| Synonyms |
Renal NAD(P)Hoxidase; Renal NAD(P)H-oxidase; RENOX; Kidney superoxideproducing NADPH oxidase; Kidney superoxide-producing NADPH oxidase; Kidney oxidase1; Kidney oxidase-1; KOX1; KOX-1
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 680 nM | Click to Show More | [27] | |
| 2 | B-Lactams | Drug Info | IC50 = 850 nM | [27] | ||
| Co-Target Name | Glycogen synthase kinase-3 beta (GSK-3B) | Clinical trial Target | ||||
| UniProt ID | GSK3B_HUMAN | |||||
| Gene Name | GSK3B | |||||
| Synonyms |
Serine/threonine-protein kinase GSK3B; GSK-3 beta
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| Representative Drug(s) | B-Lactams | Drug Info | IC50 = 800 nM | [18] | ||
| Co-Target Name | Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) | Clinical trial Target | ||||
| UniProt ID | Q965D6_PLAFA | |||||
| Gene Name | Malaria fabG | |||||
| Synonyms |
3-oxoacyl-acyl-carrier protein reductase
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| Representative Drug(s) | B-Lactams | Drug Info | Ki = 800 nM | [28] | ||
| Co-Target Name | Aurora kinase B (AURKB) | Clinical trial Target | ||||
| UniProt ID | AURKB_HUMAN | |||||
| Gene Name | AURKB | |||||
| Synonyms |
Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 12; Serine/threonine protein kinase 12; STK5; STK12; Aurora/IPL1-related kinase 2; Aurora-related kinase 2; Aurora-B; Aurora-2 kinase; Aurora-2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora 1; ARK2; ARK-2; AIRK2; AIM1; AIM-1; AIK2
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 910 nM | [11] | ||
| Co-Target Name | Matrix metalloproteinase-12 (MMP-12) | Clinical trial Target | ||||
| UniProt ID | MMP12_HUMAN | |||||
| Gene Name | MMP12 | |||||
| Synonyms |
Macrophage metalloelastase; Macrophage elastase; MME; ME; HME
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| Representative Drug(s) | B-Lactams | Drug Info | IC50 = 980 nM | [29] | ||
| Co-Target Name | Carbonic anhydrase VII (CA-VII) | Patented-recorded Target | ||||
| UniProt ID | CAH7_HUMAN | |||||
| Gene Name | CA7 | |||||
| Synonyms |
Carbonic anhydrase 7; Carbonate dehydratase VII
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| Representative Drug(s) | B-Lactams | Drug Info | Ki = 4.7 nM | [8] | ||
| Co-Target Name | Arachidonate 12-lipoxygenase (12-LOX) | Literature-reported Target | ||||
| UniProt ID | LOX12_HUMAN | |||||
| Gene Name | ALOX12 | |||||
| Synonyms |
Platelet-type lipoxygenase 12; Lipoxin synthase 12-LO; LOG12; Arachidonate 12-lipoxygenase, 12S-type; 12S-lipoxygenase; 12S-LOX; 12LO; 12-lipoxygenase
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 440 nM | [31] | ||
| Co-Target Name | Cytochrome P450 1A1 (CYP1A1) | Co-Target | ||||
| UniProt ID | CP1A1_HUMAN | |||||
| Gene Name | CYP1A1 | |||||
| Synonyms |
CYPIA1; Hydroperoxy icosatetraenoate dehydratase; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1
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| Representative Drug(s) | Quercetin | Drug Info | Ki = 660 nM | Click to Show More | [22] | |
| 2 | B-Lactams | Drug Info | Ki = 890 nM | [22] | ||
| Co-Target Name | Inositol hexakisphosphate kinase 2 (IP6K2) | Co-Target | ||||
| UniProt ID | IP6K2_HUMAN | |||||
| Gene Name | IP6K2 | |||||
| Synonyms |
InsP6 kinase 2; InsP6K2; PiUS; P(i)-uptake stimulator
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| Representative Drug(s) | Quercetin | Drug Info | IC50 = 700 nM | [32] | ||
| References | Top | ||||
|---|---|---|---|---|---|
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| REF 3 | QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors. Eur J Med Chem. 2010 May;45(5):1724-30. | ||||
| REF 4 | Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. | ||||
| REF 5 | Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. | ||||
| REF 6 | Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75. | ||||
| REF 7 | New Inhibitors of Breast Cancer Resistance Protein (ABCG2) Containing a 2,4-Disubstituted Pyridopyrimidine Scaffold. J Med Chem. 2018 Apr 26;61(8):3389-408. | ||||
| REF 8 | New natural product carbonic anhydrase inhibitors incorporating phenol moieties. Bioorg Med Chem. 2015 Nov 15;23(22):7219-25. | ||||
| REF 9 | Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. | ||||
| REF 10 | Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus. Eur J Med Chem. 2018 May 10;151:145-157. | ||||
| REF 11 | Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum. J Nat Prod. 2014 Jan 24;77(1):49-56. | ||||
| REF 12 | Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod. 1991 Jan-Feb;54(1):143-54. | ||||
| REF 13 | X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin. J Nat Prod. 2014 Jul 25;77(7):1693-9. | ||||
| REF 14 | Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75. Bioorg Med Chem. 2014 Jun 15;22(12):3146-58. | ||||
| REF 15 | Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. J Nat Prod. 1998 Jan;61(1):71-6. | ||||
| REF 16 | Flavonoids as receptor tyrosine kinase FLT3 inhibitors. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1768-70. | ||||
| REF 17 | Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors. Bioorg Med Chem. 2013 Jul 15;21(14):4301-10. | ||||
| REF 18 | Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J Med Chem. 2005 Feb 10;48(3):737-43. | ||||
| REF 19 | Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitors. Eur J Med Chem. 2009 May;44(5):1982-8. | ||||
| REF 20 | Antioxidant and alpha-glucosidase inhibitory compounds from Pimpinella candolleana Wight et Arn. Med Chem Res. 2012 Jan 18;21:4324-9. | ||||
| REF 21 | Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships. J Nat Prod. 1995 Feb;58(2):217-25. | ||||
| REF 22 | Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg Med Chem. 2011 May 1;19(9):2842-9. | ||||
| REF 23 | Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. J Med Chem. 2005 Dec 1;48(24):7604-14. | ||||
| REF 24 | Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay. Eur J Med Chem. 2010 Sep;45(9):4316-30. | ||||
| REF 25 | A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs. Bioorg Med Chem. 2019 Mar 1;27(5):677-685. | ||||
| REF 26 | Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur J Med Chem. 2011 Mar;46(3):870-6. | ||||
| REF 27 | Small-molecule inhibitors of NADPH oxidase 4. J Med Chem. 2010 Sep 23;53(18):6758-62. | ||||
| REF 28 | Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. | ||||
| REF 29 | Natural products as a gold mine for selective matrix metalloproteinases inhibitors. Bioorg Med Chem. 2012 Jul 1;20(13):4164-71. | ||||
| REF 30 | Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids. J Med Chem. 2015 Sep 24;58(18):7400-8. | ||||
| REF 31 | Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. Bioorg Med Chem. 2007 Dec 1;15(23):7408-25. | ||||
| REF 32 | Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. J Med Chem. 2019 Feb 14;62(3):1443-1454. | ||||
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