Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T35640 | Target Info | |||
| Target Name | Integrin alpha-L (ITGAL) | ||||
| Synonyms |
Lymphocyte Function-associated Antigen-1; Leukocyte function-associated molecule 1 alpha chain; Leukocyte function associated molecule 1, alpha chain; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; LFA-1; CD11a; CD11 antigen-like family member A
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| Target Type | Successful Target | ||||
| Gene Name | ITGAL | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Intercellular adhesion molecule ICAM-1 (ICAM1) | Successful Target | ||||
| UniProt ID | ICAM1_HUMAN | |||||
| Gene Name | ICAM1 | |||||
| Synonyms |
Major group rhinovirus receptor; Intercellular adhesion molecule 1; ICAM-1; CD54
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| Representative Drug(s) | lifitegrast | Drug Info | IC50 = 2.98 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Med Chem Lett. 2012 Jan 31;3(3):203-6. | ||||
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