Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T36053 | Target Info | |||
| Target Name | Organic anion transporter M1 (SLCO4C1) | ||||
| Synonyms |
Solute carrier organic anion transporter family member 4C1; Solute carrier family 21 member 20; OATPX; OATP4C1; OATP-M1; OATP-H
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| Target Type | Successful Target | ||||
| Gene Name | SLCO4C1 | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Sodium/potassium-transporting ATPase (SPT ATPase) | Successful Target | ||||
| UniProt ID | AT1A1_HUMAN; AT1A2_HUMAN; AT1A3_HUMAN; AT1B1_HUMAN; AT1B2_HUMAN; AT1B3_HUMAN | |||||
| Gene Name | ATP1A1; ATP1A2; ATP1A3; ATP1B1; ATP1B2; ATP1B3 | |||||
| Synonyms |
Na(+)/K(+) ATPase
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| Representative Drug(s) | Digoxin | Drug Info | IC50 = 270 nM | [1] | ||
| Co-Target Name | Sodium pump subunit alpha-1 (ATP1A1) | Successful Target | ||||
| UniProt ID | AT1A1_HUMAN | |||||
| Gene Name | ATP1A1 | |||||
| Synonyms |
Sodium/potassium-transporting ATPase alpha1; Sodium pump 1; Na+/K+ ATPase 1; ATP1A1
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| Representative Drug(s) | Digoxin | Drug Info | IC50 = 290 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of panaxatriol derivatives as Na. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2885-9. | ||||
| REF 2 | gamma-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect. Bioorg Med Chem. 2015 Aug 1;23(15):4397-404. | ||||
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