Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39610 | Target Info | |||
| Target Name | Calmodulin (CALM) | ||||
| Synonyms |
CaM; CALM2
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| Target Type | Successful Target | ||||
| Gene Name | CALM | ||||
| Biochemical Class | Calmodulin-dependent secretion | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Opioid receptor sigma 1 (OPRS1) | Successful Target | ||||
| UniProt ID | SGMR1_HUMAN | |||||
| Gene Name | SIGMAR1 | |||||
| Synonyms |
hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8
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| Representative Drug(s) | Trifluoperazine | Drug Info | Ki = 15 nM | [1] | ||
| Co-Target Name | Voltage-gated potassium channel Kv11.1 (KCNH2) | Successful Target | ||||
| UniProt ID | KCNH2_HUMAN | |||||
| Gene Name | KCNH2 | |||||
| Synonyms |
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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| Representative Drug(s) | Halofantrine | Drug Info | IC50 = 40 nM | [2] | ||
| Co-Target Name | Hepatitis C virus NS3 helicase (HCV NS3) | Successful Target | ||||
| UniProt ID | POLG_HCV1 (1027-1657) | |||||
| Gene Name | HCV NS3 | |||||
| Synonyms |
HCV Hepacivirin; HCV NS3P; HCV p70
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| Representative Drug(s) | Trifluoperazine | Drug Info | IC50 = 700 nM | [3] | ||
| Co-Target Name | Cholestenol delta-isomerase (EBP) | Clinical trial Target | ||||
| UniProt ID | EBP_HUMAN | |||||
| Gene Name | EBP | |||||
| Synonyms |
Emopamilbinding protein; EBP; Delta(8)Delta(7) sterol isomerase; D8D7 sterol isomerase; 3betahydroxysteroidDelta(8),Delta(7)isomerase
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| Representative Drug(s) | Trifluoperazine | Drug Info | Ki = 8 nM | [1] | ||
| Co-Target Name | Emopamil-binding protein-like (EBPL) | Co-Target | ||||
| UniProt ID | EBPL_HUMAN | |||||
| Gene Name | EBPL | |||||
| Synonyms |
Emopamil-binding-related protein
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| Representative Drug(s) | Trifluoperazine | Drug Info | Ki = 3.9 nM | [4] | ||
| References | Top | ||||
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| REF 1 | Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem. 2005 Jul 28;48(15):4754-64. | ||||
| REF 2 | The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4771-7. | ||||
| REF 3 | Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. | ||||
| REF 4 | Synthesis and biological evaluation of ??F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging. Bioorg Med Chem. 2013 Jan 1;21(1):215-22. | ||||
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