Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T40800 Target Info
Target Name Sodium pump subunit alpha-1 (ATP1A1)
Synonyms
Sodium/potassium-transporting ATPase alpha1; Sodium pump 1; Na+/K+ ATPase 1; ATP1A1
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Target Type Successful Target
Gene Name ATP1A1
Biochemical Class Acid anhydrides hydrolase
UniProt ID
AT1A1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Sodium/potassium-transporting ATPase (SPT ATPase) Successful Target
UniProt ID AT1A1_HUMAN; AT1A2_HUMAN; AT1A3_HUMAN; AT1B1_HUMAN; AT1B2_HUMAN; AT1B3_HUMAN
Gene Name ATP1A1; ATP1A2; ATP1A3; ATP1B1; ATP1B2; ATP1B3
Synonyms
Na(+)/K(+) ATPase
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Representative Drug(s) Drug Info IC50 = 3.4 ug.mL-1 [1]
Co-Target Name Human immunodeficiency virus Reverse transcriptase (HIV RT) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV RT
Synonyms
HIV p66 RT; HIV Exoribonuclease H
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Representative Drug(s) Drug Info IC50 ~ 200 ug.mL-1 [2]
Co-Target Name Voltage-gated potassium channel Kv11.1 (KCNH2) Successful Target
UniProt ID KCNH2_HUMAN
Gene Name KCNH2
Synonyms
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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Representative Drug(s) Lumefantrine Drug Info IC50 = 377 nM [3]
Co-Target Name Kruppel-like factor 5 (KLF5) Co-Target
UniProt ID KLF5_HUMAN
Gene Name KLF5
Synonyms
Krueppel-like factor 5; Basic transcription element-binding protein 2; BTE-binding protein 2; Colon krueppel-like factor; GC-box-binding protein 2; Intestinal-enriched krueppel-like factor; Transcription factor BTEB2
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Representative Drug(s) Drug Info IC50 = 164.55 nM [4]
References  Top
REF 1 Meroterpenoids from a Tropical Dysidea sp. Sponge. J Nat Prod. 2015 Nov 25;78(11):2814-21.
REF 2 Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod. 1991 Jan-Feb;54(1):143-54.
REF 3 3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally. J Med Chem. 2017 Jul 27;60(14):6036-44.
REF 4 PubChem BioAssay: 2017 update. Nucleic Acids Res. 2017 Jan 4;45(D1):D955-D963.

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