Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T45262 Target Info
Target Name Corticotropin-releasing factor receptor 1 (CRHR1)
Synonyms
Corticotropin-releasing hormone type 1 receptor; Corticotropin-releasing hormone receptor 1; CRHR1; CRH-R 1; CRF1; CRF-R1; CRF-R; CRF-1 receptor; CRF receptor
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Target Type Successful Target
Gene Name CRHR1
Biochemical Class GPCR secretin
UniProt ID
CRFR1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Corticotropin-releasing factor receptor 2 (CRHR2) Clinical trial Target
UniProt ID CRFR2_HUMAN
Gene Name CRHR2
Synonyms
Corticotropin-releasinghormone receptor 2; CRHR2; CRH2 receptor; CRH-R 2; CRF2; CRF-R 2
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Representative Drug(s) Drug Info IC50 ~ 1000 nM [1]
Co-Target Name Corticotropin-releasing factor binding protein (CRHBP) Literature-reported Target
UniProt ID CRHBP_HUMAN
Gene Name CRHBP
Synonyms
Corticotropin-releasing hormone-binding protein; Corticotropin-releasing factor-binding protein; CRH-BP; CRFBP; CRF-binding protein; CRF-BP
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Representative Drug(s) Drug Info IC50 ~ 1000 nM [2]
References  Top
REF 1 Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists. J Med Chem. 2009 May 14;52(9):3084-92.
REF 2 In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist. Drug Metab Dispos. 2012 Jun;40(6):1093-103.

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